HBsAg和HBeAg定量检测在急慢性乙型肝炎患中临床意义

目的 探讨HBsAg和HBeAg定量检测在急慢性乙型肝炎患中的临床意义.方法 选取2009年6月-2011年6月在某院治疗的156例急慢性乙型肝炎患者为研究对象,随机将156例乙肝患者分为两组,每组各78例患者,一组服用拉米夫定(A组),一组服用干扰素(B组).分别检测两组肝炎患者治疗前后的HBsAg及HBeAg值,探讨HBsAg和HBeAg定量检测在急慢性乙型肝炎患中临床意义.结果 治疗后4周A组HBsAg定量值为(2.875±0.317) ng/ml,HBeAg定量值为(2.912±0.168) ng/ml,HBV DNA定量值为(8.22×104±3.13×103)拷贝/ml;治疗后8周A组HBsAg定量值为(2.127±0.305) ng/ml,HBeAg定量值为(2.739±0.154) ng/ml,HBV DNA定量值为(2.51×104±1.11×103)拷贝/ml;治疗后24周A组HBsAg定量值为(2.012±0.265) ng/ml,HBeAg定量值为(2.153±0.047) ng/ml,HBVDNA定量值为(4.29×103±3.66×102)拷贝/ml.与B组比较差异均有统计学意义(P＜0.05).结论 通过检测HBsAg、HBeAg定量检测值的水平,能够反映出HBVDNA复制的具体情况,同时能够对临床不同方法治疗乙型肝炎的效果进行判断,从而对于下一步的治疗方法起到指导作用.

The clinical significance of the quantitative detection of HBsAg and HBeAg in acute and chronic hepatitis B

OBJECTIVE To investigate the clinical significance of the quantitative detection of HBsAg and HBeAg in acute and chronic hepatitis B.METHODS 156 cases of acute and chronic hepatitis B patients treated in our hospital from June 2009 to June 2011 were chosen as the research objects.156 cases of hepatitis B patients were randomly divided into two groups,each group of 78 cases of patients,one group was given lamivudine(group A),and another group was given interferon(group B).The HBsAg and HBeAg values for the two groups before and after treatment were detected,and explored the clinical significance of the quantitative detection of HBsAg and HBeAg in acute and chronic hepatitis B.RESULTS After 4 weeks,quantitative HBsAg in group A was(2.875 ± 0.317) ng /ml,HBeAg quantitative value was(2.912 ± 0.168) ng /ml,HBV DNA quantitative value was(8.22×104 ± 3.13×103) copies /ml.8 weeks after treatment in group A quantitative HBsAg value was(2.127 ± 0.305) ng /ml,HBeAg quantitative value was(2.739 ± 0.154) ng /ml,HBV DNA quantification value was(2.51× 104 ± 1.11×103) copies /ml.24 weeks after treatment,quantitative HBsAg value in group A was(2.012 ± 0.265) ng /ml,HBeAg quantitative value was(2.153 ± 0.047) ng /ml.HBV DNA quantification value was(4.29×103 ± 3.66×102) copies /ml.Compared with B group,the differences were statistically significant(P﹤0.05).CONCULSION The HBsAg,HBeAg quantitative detection level reflects the specific circumstances of HBV DNA copy,while provides the ability to judge the effect of the different methods of treatment for clinical hepatitis B,which plays a guiding role for the next treatment method.