黄连素联合二甲双胍治疗2型糖尿病合并非酒精性脂肪肝的临床观察

目的 观察黄连素联合二甲双胍治疗2型糖尿病合并非酒精性脂肪肝的疗效及安全性.方法 选择初诊2型糖尿病合并非酒精性脂肪患者78例,治疗组(黄连素+二甲双胍)38例和对照组(二甲双胍)40例.治疗前后测定体重指数(BMI)、FPG、2hPG、HbA1c、FINS,血脂(TC、TG、HDL-C、LDL-C),肝功能(AST、ALT、GGT),计算胰岛素抵抗指数(HOMA-IR).观察期16周.结果 与对照组相比,治疗组可进一步降低血糖、减轻体重、增加胰岛素敏感性(P＜ 0.05);治疗组的血脂、肝功能的改善明显优于对照组(P＜0.01).结论 黄连素联合二甲双胍治疗2型糖尿病合并NAFLD具有一定的疗效.

clinical observation on the Berberine plus metformin in treatment of type 2 diabetes complicated by nonalcoholic fatty liver disease

OBJECTIVE To observe the effect of berberine plus metformin in treatment of type 2 diabetes complicated by nonalcoholic fatty liver disease.METHODS Seventy-eight patients with newly-diagnosed type 2 diabetic complicated by nonalcoholic fatty liver disease(NAFLD)were collected.There were 38 cases in the treatment group(berberine + metformin)and 40 cases in the control group(metformin).Fasting blood glucose,2-hour postprandial blood glucose,fasting blood insulin,glycosylated hemoglobin,insulin resistance index,blood lipid(TC,TG,HDL-C,LDL-C),liver function(AST,ALT,GGT),body mass index(BMI)were measured before and after the treatment.The follow-up period was 16 weeks.RESULTS Treatment group can further reduce blood glucose,weight loss,increased insulin sensitivity compared with those in control group(P﹤0.05);The liver function and blood lipid of treatment group were significantly improved than those in the control group(P﹤0.01).CONCLUSION Berberine plus metformin was effective in patients with type 2 diabetes mellitus complicated by NAFLD.