血清同型半胱氨酸、胆红素、尿酸水平检测在冠状动脉病变患者中的意义

目的 探讨血清同型半胱氨酸、胆红素、尿酸水平检测在冠状动脉病变患者中的意义.方法 2010年1月～2011年12月,分别检测600例冠心病(CHD)患者[其中稳定性心绞痛(SAP) 132例,不稳定心绞痛(UAP) 171例,急性非Q波心肌梗死(NQMI) 153例和急性Q波心肌梗死(QMI) 144例]和300健康对照者血清同型半胱氨酸、胆红素、尿酸水平.结果 CHD组血清同型半胱氨酸、总胆红素和尿酸水平明显高于对照组(P＜0.05).UAP组血清同型半胱氨酸、总胆红素和尿酸水平明显高于SAP组(P＜ 0.05); QMI组和NQMI组血清同型半胱氨酸、总胆红素和尿酸水平明显高于UAP组和SAP组(P＜0.05),而QMI组和NQMI组血清同型半胱氨酸、总胆红素和尿酸水平比较,差异无统计学意义(P＞0.05).结论 血清同型半胱氨酸、总胆红素和尿酸水平检测对于诊断CHD,判断CHD患者的病情具有重要意义,及早改善其在血中的浓度,有助于延缓动脉粥样硬化的发展.

Significance of serum homocysteine, bilirubin and uric acid detection in patients with coronary heart disease

OBJECTIVE To discuss the significance of serum homocysteine, bilirubin and uric acid in detecting patients with coronary heart disease. METHODS From January 2010 to December 2011, the serum levels of homocysteine, bilirubin and uric acid in 600 cases with coronary heart disease (CHD) [132 cases with stable angina pectoris (SAP), 171 cases with un- stable angina pectoris (UAP), 153 cases with non-Q-wave myocardial infarction (NQMI) and 144 cases with Q-wave myocar- dial infarction (QMI)] and 300 cases healthy controls were detected by particles enhance the immune turbidimetric method and enzymatic cycling method, respectively. RESULTS The levels of serum homocysteine, bilirubin and uric acid in CHD group were significantly higher than those in control group (P﹤0.05). The levels of serum homocysteine,, bilirubin and uric acid in UAP group were significantly higher than those in SAP group (P﹤0.05). The levels of serum homocysteine, bilirubin and uric acid in QMI group and NQMI group were significantly higher than those in UAP group and SAP group (P ﹤ 0.05) , while no significant difference was found between QMI group and NQMI group ( P ﹥ 0.05). CONCLUSION The serum homocysteine, bilirubin and uric acid have important significance for diagnosing CHD and judging ill states, and lowing their concentration ear- ly is good for delaying the development of atherosclerosis.