子痫前期患者凝血指标的监测及其临床意义

目的 探讨子痫前期患者血浆凝血指标的变化及意义。方法 采用非妊娠妇女组40例（对照组）、正常晚期妊娠组40例、子痫前期组40例进行血浆凝血指标的监测分析。结果 子痫前期组与对照组比较：凝血酶原时间缩短PT、纤维蛋白原增高Fib、D-二聚体升高，差异具有统计学意义（P＜0.05）；子痫前期组与正常晚期妊娠组比较，凝血酶时间缩短TT、纤维蛋白原增高Fib、D-二聚体升高，差异具有统计学意义（P＜0.05）。结论 子痫前期患者存在凝血功能异常与纤溶抑制功能亢进，提示监测发现凝血指标明显异常者，有利于指导高危妊娠临床诊断、早期干预，预防产后出血、DIC等分娩期并发症的发生。

The monitoring and significance in plasma coagulation of preeclampsia patients

ObjectiveDiscussion the significance and changes in plasma coagulation of preeclampsia patients. MethodsMonitoring and analysis of plasma coagulation of 40 non-pregnant women (the control group), 40 normal late pregnancy and 40 preeclampsia. ResultsPreeclampsia compare with the control：prothrombin time shortened, fibrinogen elevated, D-dimer elevated，statistically significant difference（P<0.05）; preeclampsia compare with normal late pregnancy: prothrombin time shortened，fibrinogen elevated, D-dimer elevated，statistically significant difference（P<0.05）. ConclusionThere are coagulopathy and fibrinolysis hyperthyroidism in the preeclampsia patients, which prompts detected significant abnormalities in coagulation is benefit to guide the clinical diagnosis of high-risk pregnancy, early intervention, prevention of postpartum hemorrhage, DIC and other intrapartum complications.