| CYP1A1rs4646903单核苷酸多态性与宁夏地区男性不育相关性研究 |
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| 引用本文： | 彭亮,王钢,焦海燕,李元杰,党洁.CYP1A1rs4646903单核苷酸多态性与宁夏地区男性不育相关性研究[J].宁夏医科大学学报,2012,34(3):208-210,317. |
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| 作者姓名： | 彭亮 王钢 焦海燕 李元杰 党洁 |
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| 作者单位： | 彭亮 (宁夏医科大学医学遗传学与细胞生物学系,银川,750004) ； 王钢 (宁夏回族自治区生殖与遗传重点实验室,银川,750004) ； 焦海燕 (宁夏回族自治区生育力保持省部共建教育部重点实验室,银川,750004) ； 李元杰 (宁夏回族自治区生殖与遗传重点实验室,银川,750004) ； 党洁 (宁夏医科大学医学遗传学与细胞生物学系,银川,750004) ； |
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| 基金项目： | 宁夏自然科学基金,宁夏医科大学校级科研项目 |
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| 摘 要： | 目的分析CYP1A1(rs4646903,T/C)单核苷酸多态性与宁夏地区男性不育的相关性。方法采用病例-对照研究方法,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术分别对204例男性不育患者和202例正常男性对照的CYP1A1 rs4646903单核苷酸多态性进行测定,分析基因型及等位基因频率在患者组和对照组的分布特点。结果相对于纯合野生基因型TT,未见CYP1A1 rs4646903杂合突变型TC(OR=1.07,95%CI=0.70～1.65)和纯合突变型CC(OR=1.41,95%CI=0.79～2.50)与男性不育有关联(P>0.05)。此外,相对于野生基因T,也未见突变基因C与男性不育有关联(OR=1.17,95%CI=0.88～1.55)。结论 CYP1A1 rs4646903单核苷酸多态性与宁夏地区男性不育无相关性。
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| 关 键 词： | 男性不育 细胞色素p4501A1 单核苷酸多态性 |
Relationship between CYP1A1 rs4646903 Gene Polymorphism and Male Infertility in Ningxia |
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| PENG Liang,WANG Gang,JIAO Hai-yan,LI Yuan-jie,DANG Jie.Relationship between CYP1A1 rs4646903 Gene Polymorphism and Male Infertility in Ningxia[J].Journal of Ningxia Medical College,2012,34(3):208-210,317. |
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| Authors: | PENG Liang WANG Gang JIAO Hai-yan LI Yuan-jie DANG Jie |
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| Institution: | 1,2,3( 1. Department of Medical Genetics and Cell Biology,Ningxia Medical University,Yinchuan 750004; 2. Key Laboratory of Reproduction and Genetics in Ningxia,Yinchuan 750004; 3. Key laboratory of Fertility Preservation and Maintenance,Ningxia Medical University,Ministry of Education,Yinchuan 750004) |
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| Abstract: | Objective To investigate the association between CYP1A1 gene rs4646903 polymorphism and its susceptibility to male infertility in Ningxia.Methods CYP1A1 gene rs4646903 polymorphism in 204 cases with male infertility and 202 controls were detected by PCR-RFLP.The frequencies of genotype and allele were analyzed.Results There was no significant difference in the genotype TT,TC,CC between the two groups(P > 0.05).Compared with wild type TT,the odds ratio(OR) of male infertility with genotypes of heterozygote TC and homozygote CC were 1.07(95% CI: 0.70 ～ 1.65) and 1.41(95% CI: 0.79 ～ 2.5),respectively.The frequencies of allele T and C showed no significant difference between the two groups(P > 0.05).OR of male infertility with the allele C was 1.17(95% CI: 0.88 ～ 1.55).Conclusion There was no relationship between CYP1A1 gene rs4646903 polymorphism and male infertility in Ningxia. |
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| Keywords: | male infertility CYP1A1 single-nucleotide polymorphism |
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