| 退变腰椎间盘髓核中PDCD5的表达 |
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| 引用本文： | 蔡利军,邢乾君,贺海燕,王一农.退变腰椎间盘髓核中PDCD5的表达[J].宁夏医学杂志,2012,34(2):106-107. |
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| 作者姓名： | 蔡利军 邢乾君 贺海燕 王一农 |
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| 作者单位： | 蔡利军 (宁夏自治区人民医院骨科,宁夏,银川,750021) ； 邢乾君 (宁夏友谊慈善医院,宁夏,银川,750004) ； 贺海燕 (宁夏自治区人民医院骨科,宁夏,银川,750021) ； 王一农 (宁夏自治区人民医院骨科,宁夏,银川,750021) ； |
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| 摘 要： | 目的测定程序化死亡基因5(PDCD5)在退变椎间盘髓核中的表达,研究PDCD5表达与腰椎间盘退变的相关性。方法通过免疫组织化学方法检测26例腰椎间盘突出症患者及10例腰椎骨折患者髓核标本中PD-CD5的表达,并进行比较分析。结果椎间盘突出组髓核中PDCD5表达阳性率达73.1%,与对照组(30%)相比差异有统计学意义(P<0.05)。PDCD5表达的高低与椎间盘退变程度有一定相关性(r=0.365)。结论 PDCD5在不同椎间盘髓核中均有表达,提示PDCD5参与了椎间盘退变过程,在椎间盘退变过程中发挥了一定的作用。
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| 关 键 词： | PDCD5 椎间盘 免疫组织化学 |
Expression of PDCD5 in degenerative human lumbar intervertebral discs |
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| Institution: | Cai li-jun, et-al; |
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| Abstract: | Objective To investigate the expression of PDCD5 in degenerative human lumbar intervertebral discs, and to research the relationship between PDCD5 and the human lumbar intervertebral discs degeneration. Methods PDCD5 were measured by immunohistochemistry staining in 26 protruded lumbar intervertebral discs tissues (degeneration group )and 10 nondegenerste lumbar discs tissues(control group ).Results The expression of PDCD5 in Nucleus Pulposus tissues in degeneration group was significantly higher than in control group(P＜0.05). Conclusion The expression of PDCD5 was positive in two groups ,the positive rate of PDCD5 expression in degeneration group was significantly higher than control group.The finding suggest that PDCD5 was involved in pathomechanism of lumbar intervertebral disc degeneration. |
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| Keywords: | programmed cell death 5 intervertebral disc immunohistochemistry |
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