| 212例白血病患者染色体分析 |
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| 引用本文： | 王贵杰,夏新舍,杨宝珍.212例白血病患者染色体分析[J].宁夏医科大学学报,2012,34(4):349-352. |
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| 作者姓名： | 王贵杰 夏新舍 杨宝珍 |
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| 作者单位： | 王贵杰 (宁夏医科大学总医院医学实验中心,银川,750004) ； 夏新舍 (宁夏医科大学总医院医学实验中心,银川,750004) ； 杨宝珍 (宁夏医科大学总医院医学实验中心,银川,750004) ； |
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| 摘 要： | 目的分析各类白血病染色体的异常改变。方法采用直接法和短期培养法制备骨髓或外周血细胞染色体,R显带和(或)G显带分析212例白血病患者骨髓细胞染色体。结果 98例急性髓性白血病检出异常核型63例,异常发生率占64.3%;48例急性淋巴细胞白血病检出异常核型34例,异常发生率占70.8%;52例慢性粒细胞白血病检出异常核型51例,异常发生率占98.1%,14例慢性淋巴细胞白血病检出异常核型5例,异常发生率占35.7%。结论大多数白血病伴有染色体畸变,染色体核型分析是白血病重要的辅助诊断、分型的指标之一。
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| 关 键 词： | 白血病 诊断 核型分析 |
Chromosome Analysis in 212 Cases with Leukemia |
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| WANG Gui-jie,XIA Xin-she,YANG Bao-zhen.Chromosome Analysis in 212 Cases with Leukemia[J].Journal of Ningxia Medical College,2012,34(4):349-352. |
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| Authors: | WANG Gui-jie XIA Xin-she YANG Bao-zhen |
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| Institution: | (Medical Experiment Center,the General Hospital of Ningxia Medical University,Yinchuan 750004) |
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| Abstract: | Objective To analyze the chromosome abnormality in 212 cases with leukemia.Methods Specimens of bone marrow or blood cell were processed using direct methods,short-term cultures,or both.Karyotype analysis was performed by R/G banding technique in 212 patients with leukemia respectively.Results 63 cases were found chromosomal aberrations among 98 cases with AML and the chromosome aberrations incidence was 64.3%.ALL had 70.8%(34 cases)chromosome abnormality in 48 cases.Chromosome abnormality was 98.1%(51 cases)in 52 cases with CML,while chromosome abnormality was 35.7%(5 cases)in 14 cases with CLL.Conclusion Most leukemias have chromosome abnormality.Cytogenetics is an important diagnostic and typing reference to leukemia. |
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| Keywords: | leukemia diagnosis karyotype analysis |
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