高低频率结合喷射通气的动物实验及临床观察

本文应用高频喷射振荡（ＨＦＪＯ）、低频喷射通气（ＬＦＪＶ）以及高频喷射振荡叠加低频喷射通气（ＨＦＪＯ＋ＬＦＪＶ）三种通气方式，观察对无自主呼吸犬的氧合及ＣＯ＿２排出的效果。三种通气方式都能维持较好的氧合，但ＨＦＪＯ＋ＬＦＪＶ能有效地排出ＣＯ＿２，防止ＣＯ＿２潴留。临床应用观察到，对于快速静脉诱导的无自主呼吸的麻醉病人，和ＨＦＪＯ相比，ＨＦＪＯ＋ＬＦＪＶ在气道内平均压无明显增加的情况下，可使病人体内ＣＯ＿２有效地排出，维持动脉血ｐＨ在正常范围。我们认为，在气道开放状态下ＨＦＪＯ＋ＬＦＪＶ能增强ＣＯ＿２的排出，维持正常的气体交换，不产生对循环的不良影响。

Animal Experiment and Clinical Observation of Combined Jet Ventilation

High frequency jet oscillation(HFJO),low frequency jet ventilation(LFJV)and HFJO com-bined with LFJV(HFJO LFJV)were used to ob-serve their effects on oxygenation and CO_2 elimina-tion of dogs without autonomic breath. The resultsrevealed that all of the three Kinds of ventilationshave efficient oxygenation, but HFJO LFJV couldeffectively eliminate CO_2, preventing the retention ofCO_2. Clinical observation revealed that, for the anes-thetized patients without autonomic breath,com-pared with HFJ0, HFJO LFJV effectively eliminat-ed CO_2 and maintained the normal pH, while themean airway pressures were not increased. We con-clude that, with the airway open, HFJO LFJVcould enhance the elimination of CO_2, maintain thenormal gases exchange and don't interfere with bloodcirculation.