黄连素的生物学功能及治疗口腔疾病研究的进展

黄连素(小檗碱)是从黄连、三颗针、黄柏等天然药物中提取的异喹啉类生物碱,具有广泛的药理作用,能够有效地抗惊厥、抗高血压、抗肿瘤、抗抑郁、抗炎、降血脂、降血糖等。近年来,由于其丰富的生物学功能,人们逐渐发掘出黄连素用于治疗口腔疾病的潜力,研究其与龋病、根尖周炎、牙周病、口腔黏膜病、颌面部肿瘤的关系。本文就黄连素的生物学功能和其在口腔领域中的研究进展作一综述,为进一步研究黄连素在治疗口腔疾病的应用提供参考。

Progress for understanding the effect of berberine in oral diseases

Berberine is a benzylisoquinoline alkaloid, occurring as one of the main active ingredients in many traditional herbs including coptis, barberry, phellodendron. Several studies have depicted its anticonvulsant, antihypertensive, antidepressant, anti-inflammatory, hypolipidemic, and antidiabetic biological effect. Depending on a rich and varied biological function, the potential of berberine for curing oral diseases has been discovered recently. Researchers focus on the relation of berberine to oral diseases, such as periodontitis, caries, periapical periodontitis, diseases of oral mucosa, oral/maxillofacial. The review pays attention to the biological function of berberine as well as its roles in oral diseases.