Pancreatic perivascular epithelioid cell tumor: A case report with clinicopathological features and a literature review |
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Authors: | Hui Jiang Na Ta Xiao-Yi Huang Ming-Hua Zhang Jing-Jing Xu Kai-Lian Zheng Gang Jin Jian-Ming Zheng |
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Affiliation: | Hui Jiang, Na Ta, Xiao-Yi Huang, Ming-Hua Zhang, Jing-Jing Xu, Jian-Ming Zheng, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, ChinaKai-Lian Zheng, Gang Jin, Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China |
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Abstract: | Perivascular epithelioid cell tumor(PEComa) of the pancreas is an unusual tumor deriving from mesenchyma. This paper described a case of pancreatic PEComa, which was initially suspected as neuroendocrine carcinoma by biopsy, and therefore surgical treatment was recommended due to undetermined diagnosis. Examination of the surgical specimen under a microscope showed that the tumor cell's morphology was epithelioid or spindle-shaped, and ranged in a nested pattern. Additionally, these cells had a large extent of acidophilic cytoplasm, no mitotic figures, and expressed HMB-45, melan-p, and smooth muscle actin immunohistochemically. Pathological examination indicated that PEComa originated from the pancreas, but symptoms related to tuberous sclerosis were absent. Since PEComa is extremely rare in the pancreas, it is likely to be ignored in differential diagnosis. In conclusion, our article highlighted the clinicopathological features of PEComa, and we conducted a literature review focusing on PEComa so as to deepen the understanding of this tumor type. |
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Keywords: | Pancreas Perivascular epithelioid cell tumor HMB-45 Immunohistochemistry Clinicopathological feature |
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