Role of NK,NKT cells and macrophages in liver transplantation |
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| Authors: | René Fahrner Felix Dondorf Michael Ardelt Utz Settmacher Falk Rauchfuss |
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| Affiliation: | René Fahrner, Felix Dondorf, Michael Ardelt, Utz Settmacher, Falk Rauchfuss, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany |
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| Abstract: | Liver transplantation has become the treatment of choice for acute or chronic liver disease. Because the liver acts as an innate immunity-dominant organ, there are immunological differences between the liver and other organs. The specific features of hepatic natural killer(NK), NKT and Kupffer cells and their role in the mechanism of liver transplant rejection, tolerance and hepatic ischemia-reperfusion injury are discussed in this review. |
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| Keywords: | Liver transplantation Natural killer cells Kupffer cells Graft rejection Ischemia-reperfusion injury |
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