COPD病人急性发作期C反应蛋白与纤维蛋白原变化

目的探讨慢性阻塞性肺疾病（COPD）急性发作期病人血清C反应蛋白（CRP）和纤维蛋白原（Fbg）的含量变化及临床意义。方法采用速率散射比浊法分别检测30例COPD病人急性发作期、缓解期及30例体检者血清CRP、Fbg的含量,同时测定其1 s用力呼气容积占预计值百分数（FEV1%）及动脉血氧分压（PaO2）。结果COPD病人急性发作期及缓解期血清CRP及Fbg水平较对照组均明显升高,差异有显著性（F=151.61、70.45,q=7.12～22.40,P〈0.05、0.01）。急性发作期病人治疗后处于缓解期时CRP及Fbg水平均明显降低,差异有显著性（q=20.06、9.61,P〈0.05、0.01）。血清CRP及Fbg水平与FEV1%及PaO2均呈负相关（r=-0.82～-0.68,P〈0.01）。结论检测血清CRP、Fbg对于COPD急性发作期病情和疗效判断有一定意义。

C-REACTIVE PROTEIN AND FIBRINOGEN IN PATIENTS WITH ACUTE EPISODE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Objective To investigate the changes of serum C-reactive protein （CRP） and fihrinogen （Fbg） in patients with acute exacerbation of chronic obstructive pulmonary disease （COPD）. Methods The serum CRP and Fbg were detected in COPD patients during acute episode and remission, and healthy subjects, 30 persons respectively. Results The CRP and Fbg levels were higher in the patients, during acute episode and remission, than that in the controls （F= 151. 61,70.45;P〈0.05, 0.01）. After treatment,the CRP and Fbg in the patients with acute episode declined （q = 20.06,9.61;P〈0.05）. The CRP and Fbg were negatively correlated with the FEV1% （r= -0.82～-0.68,P〈0.01）. Conclusion The determination of serum CRP and Fbg is of definite significance in assessment of status and therapy of COPD at its acute exacerbation.