子宫内膜息肉组织ERα、ERβ、PR及Bcl-2表达及意义

目的 探讨生育期妇女子宫内膜息肉组织中雌激素受体α（ERα）、雌激素受体β（ERβ）、孕激素受体（PR）及Bcl-2的表达及意义。方法 用免疫组织化学PV 6000法,检测110例子宫内膜息肉组织ERα、ERβ、PR及Bcl-2的表达,并采用Image Pro Plus 6.0图像分析软件进行分析。以45例正常子宫内膜作对照。结果 在增殖期,内膜息肉组织中ERα及ERβ的表达水平与正常子宫内膜比较差异无统计学意义（P〉0.05）,而PR的表达水平低于正常内膜（t=2.589,P〈0.05）,Bcl-2的表达水平高于正常内膜（t=2.716,P〈0.01）。在分泌期,内膜息肉组织中ER-α及Bcl-2表达水平高于正常子宫内膜,PR的表达水平低于正常子宫内膜,差异均有显著性（t=2.574、2.581、2.579,P〈0.05）,ERβ的表达水平与正常内膜比较差异无统计学意义（P〉0.05）。结论 ERα、Bcl-2的高表达和PR相应的低表达可能是子宫内膜息肉形成的病因,ERα可能是在子宫内膜息肉形成过程中发挥主要作用的雌激素受体亚型。

THE EXPRESSIONS AND THEIR SIGNIFICANCE OF ERct,ERp,PR AND Bcl-2 IN ENDOMETRIAL POLYPS

Objective To investigate the expressions and their significance of estrogen receptor α （ERα）, estrogen receptor β （ERβ）, progesterone receptor （PR） and Bcl-2 in endometrial polyps of women at reproductive age. Methods Endometrium was collected from 110 patients with endometrial polyps （EP） and 45 normal controls. Immunohistochemistry of PV 6000 was used to detect the expressions of ERα,ERβ,PR and Bcl 2, Image Pro Plus 6.0 software was used to analyze the images. Results During proliferative phase, the ERa and ERα in EP group was not statistically different compared with the control （P〉0. 05） ; whereas PR was significantly lower 0=2. 589,P〈0.05） and Bcl-2 was higher （t=2. 716,P〈0. 01） in the EP group compared with the control. During secretory phase, the ERα and Bcl-2 were higher and PR was lower in the EP group than in the control t=2. 574, 2. 581,2. 579;P〈0.05）. There was no significant difference in the expression of ERβ between the two groups （P〉0. 05）. Conclusion The higher expression of ERα and Bel-2, as well as lower expression of PR may contribute to the development of endometrial polyps. ERα might be the major subtype of estrogen receptor playing a critical role in the formation of endometrial polyps.