| 吲哚-2,3-二酮的抗炎药理作用 |
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| 引用本文： | 黄霞,刘占涛,杨丽卿,申红霞,岳旺. 吲哚-2,3-二酮的抗炎药理作用[J]. 康复与疗养杂志, 2008, 0(3): 258-259 |
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| 作者姓名： | 黄霞 刘占涛 杨丽卿 申红霞 岳旺 |
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| 作者单位： | 青岛大学医学院药学系,山东青岛266021 |
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| 摘 要： | 目的 探讨吲哚-2,3-二酮的抗炎药理作用,为临床应用提供依据。方法 制备二甲苯致小鼠耳部炎症、琼脂致大鼠足肿胀急性炎症模型,观察吲哚-2,3-二酮对小鼠耳部和大鼠足肿胀程度的影响。结果 吲哚-2,3-二酮可抑制二甲苯所致的小鼠耳肿胀,且呈明显的剂量依赖关系;对大鼠琼脂性足肿胀亦有明显抑制作用。结论 吲哚-2,3-二酮有抗炎作用。
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| 关 键 词： | 吲哚-2 3-二酮 炎症 药理学 |
STUDY ON THE ANTI-INFLAMMATORY EFFECT OF 2,3-DIOXOINDOLINE |
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| Affiliation: | HUANG XIA, LIU ZHAN-TAO, YANG LI- QING, et al (Department of Pharmacology, Qingdao University Medical College, Qingdao 266021, China) |
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| Abstract: | Objective To study the anti-inflammatory action of 2,3-dioxoindoline. Methods A mouse model of the xylene induced ear inflammatory and the rat model of agar-induced hind paw edema were established. Anti-inflammatory effect of 2, 3-dioxoindoline on mouse ear swelling and rat hind paw edema was observed. Results 2,3-dioxoindoline produced obvious inhibitory effect on the mouse ear swelling and the rat hind paw edema in a dose-dependent manner. Conclusion 2,3-dioxoindoline posesses the anti inflammatory action. |
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| Keywords: | 2,3 Dioxoindoline Inflammation Pharmacology |
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