透析前慢性肾脏病患者的微炎症状态与心血管风险

目的了解GFR（15—59）mL／（min·1．73m^2）的CKD患者微炎症状态的发生率。方法观察CKDⅢ-Ⅳ期患者36例，与29例健康对照者以及32例ESRD患者比较，分析其炎症指标血白介素-6（IL-6）、肿瘤坏死因子Ⅱ（TNF-α）、同型半胱氨酸（Hcy）、超敏C反应蛋白（hscRP）。结果CKDⅢ-Ⅳ期的患者与ESRD患者的IL-6、TNF-α、Hcy、hsCRP均较正常人群偏高（P〈0．05）。结论在CKDⅢ-Ⅳ期患者中已经普遍存在微炎症状态。

The Microinflammatory Status and Cardiovascular Risk in the Pre-dialysis Chronic Kidney Disease Patients

Objective To investigate the morbidity of microinflammatory status in pre-dialysis chronic kidney disease patients. Methods 97 cases were enrolled,classified as three groups：group 1：36 patients in CKD stage Ⅲ-Ⅳ;group 2：29 healthy controlled patients;group 3：32 end stage renal disease patients without dialysis. We performed interleukin-6,Tumor necrosis factor-alpha,homocysteine and high-sensitivity C-reactive protein to evaluate microinflammatory status. Results Compared to the healthy group,the CKD patients in stage Ⅲ-Ⅳ showed higher IL-6,TNF-α ,Hcy,hsCRP as well as the ESRD patients（P〈0.05）,there was no difference between those two groups except the ESRD patients showed the most higher Hcy and hs-CRP levels （P〈0.05）. Conclusion Microin- flammatory status is really present in chronic kidney disease stage Ⅲ-Ⅳ patients.