LL-37在幽门螺杆菌相关性胃炎中的表达及临床意义 |
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引用本文: | 周刚,李之印,王仲略,沈慧琳.LL-37在幽门螺杆菌相关性胃炎中的表达及临床意义[J].中国现代医生,2011,49(11):21-22. |
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作者姓名: | 周刚 李之印 王仲略 沈慧琳 |
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作者单位: | 杭州市第二人民医院消化科,浙江杭州,310015 |
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摘 要: | 目的检测LL-37在幽门螺杆菌(Hp)相关性胃炎胃黏膜上皮中的表达,评价其在Hp感染的胃黏膜表面的抗菌作用。方法随机选择患者36例,取胃窦黏膜组织,以快速尿素酶及改良Giemsa染色两种方法判断Hp的存在与否。两者同时阳性诊断为Hp阳性,同时阴性为Hp阴性。采用免疫组织化学技术(IHC)检测36例胃炎患者的病变黏膜组织中LL-37蛋白的表达。结果IHC结果显示,LL-37在所有样本中均呈阳性胞质染色。22例幽门螺杆菌阳性胃黏膜均呈中一强阳性染色,幽门螺杆菌阴性胃黏膜组中LL-37为弱阳性染色,差异具有显著性(P〈0.05)。LL-37的表达量与幽门螺杆菌定植数量无明显相关(P〉0.05)。结论LL-37可能因Hp感染诱导呈上调表达,在Hp相关性胃炎中起到一定的抗菌作用。
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关 键 词: | LL-37 幽门螺杆菌 胃炎 |
The Expression and Clinical Significance of LL-37 in Helicobacter Pylori Induced Gastritis |
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Authors: | ZHOU Gang Li Zhiyin WANG Zhonglve SHEN Huilin |
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Institution: | ZHOU Gang LI Zhiyin WANG Zhonglve SHEN Huilin Department of Gastroenterology,Hangzhou Second People's Hospital,Hangzhou 310015,China |
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Abstract: | Objective To investigate the expression of LL-37 in Helicobacter pylori(Hp) induced gastritis and to evaluate the antibacterial role of LL-37 against Hp.Methods Biopsied gastric mucosa specimens from Hp positive(n=22) and Hp negative(n=14) individuals were used.Hp was detected by urease test and histological examination.Immunohistochemistry method was used to detect the LL-37 expression at protein level.T-test was used for data analysis.Results Positive staining of LL-37 was found in all samples in Hp posit... |
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Keywords: | LL-37 |
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