Study on HLA System in IgA Nephropathy |
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| Authors: | Kiyotaka Komori Yoshisuke Nose Hiroo Inouye Kimiyoshi Tsuji Yasuo Nomoto Hideto Sakai |
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| Affiliation: | Department of Transplantation, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan;Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan |
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| Abstract: | Forty Japanese patients with IgA nephropathy were typed for HLA-A and HLA-B using local antisera. Thirty-seven of these patients were typed for HLA-D using homozygous cells "En", now known to be strongly related to DRw6. Forty-six patients with chronic hemodialysis were used as patient controls for renal disease and 115 healthy individuals were used as normal controls. The frequency of HLA-DEn was significantly increased in 17 out of 37 patients with IgA nephropathy, (46%) (normal controls 18.3%) (P less than 0.0007). Although the occurrence of HLA-B12 was high, it was not significant, i.e. 11 out of 40 (27.5%). These results suggest that some abnormality in the genes of patients with IgA nephropathy is more closely associated with the HLA-D region than the HLA-A or B regions. |
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