| 维生素C催化合成阿司匹林的条件研究 |
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| 引用本文： | 聂鑫,翁铭图,崔剑清,徐振群,侯伟乐. 维生素C催化合成阿司匹林的条件研究[J]. 中国医药导报, 2009, 6(21): 58-58,83 |
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| 作者姓名： | 聂鑫 翁铭图 崔剑清 徐振群 侯伟乐 |
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| 作者单位： | 佛山科学技术学院医学院,广东佛山,528000 |
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| 摘 要： | 目的:以维生素C为催化剂、水杨酸为原料、醋酐为酰化剂,合成阿司匹林.方法:采用乙酰化法合成.结果:初步确定了合成条件,温度为80℃,反应时间为40 min,维生素C用量为0.2 g,收率为56.8%.结论:本方法可行,合成条件需进一步完善.
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| 关 键 词： | 维生素C 合成条件 阿司匹林 研究 |
Condition investigation on the synthesis of Aspirin by vitamin C catalyst |
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| NIE Xin,WENG Mingtu,CUI Jianqing,XU Zhenqun,HOU Weile. Condition investigation on the synthesis of Aspirin by vitamin C catalyst[J]. China Medical Herald, 2009, 6(21): 58-58,83 |
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| Authors: | NIE Xin WENG Mingtu CUI Jianqing XU Zhenqun HOU Weile |
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| Abstract: | Objective: To synthesize Aspirin by using vitamin C as the catalyst, salicylic acid as the raw material and acetic anhydride as the acylating agent. Methods: The method of acetylation was used. Results: The synthesis conditions was determined, the temperature was 80℃, the reaction time was 40 min, the quantity of vitamin C was 0.2 g, the yield was 56.8%. Conclusion: The method is feasible, and the synthesis condition needs to be improved. |
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| Keywords: | Vitamin C Synthesis condition Aspirin Research |
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