| 氯氰菊酯的检测方法及其在大鼠体内毒代动力学研究 |
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| 引用本文： | 宋亚娟,丁国华,刘扬,孙捷文,刘大洋. 氯氰菊酯的检测方法及其在大鼠体内毒代动力学研究[J]. 工业卫生与职业病, 2010, 0(1) |
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| 作者姓名： | 宋亚娟 丁国华 刘扬 孙捷文 刘大洋 |
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| 作者单位： | 黑龙江省中医研究院;黑龙江省劳动卫生职业病研究院; |
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| 基金项目： | 黑龙江省科技攻关课题(2004G0916-00) |
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| 摘 要： | 目的建立大鼠血浆和组织中氯氰菊酯的检测方法,并研究其在大鼠体内的毒代动力学规律及组织分布。方法大鼠静脉注射给药(氯氰菊酯2 mg/kg)后,采集血液及组织样品,气相色谱-电子捕获(GC-ECD)法测定血浆和组织中氯氰菊酯的浓度,计算毒代动力学参数并比较各组织中药物浓度。结果氯氰菊酯静脉注射后,在大鼠体内符合二室模型过程,主要的毒代动力学参数:Cmax为(1.984±0.219)μg/ml,t1/2α为(4.174±0.912)min,t1/2β为(46.481±12.033)min,AUC为(59.201±15.249)mg.min/L,CL为(0.034±0.009)L/min。大鼠静脉注射氯氰菊酯120 min后,在肾和心脏中的浓度高于血浆,各组织中的浓度顺序依次为:肾心肺肝脑。结论建立灵敏可靠的血和组织中氯氰菊酯定量的检测方法,可明确其在大鼠的毒代动力学过程。
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| 关 键 词： | 氯氰菊酯 血浆 组织 GC-ECD检测法 毒代动力学 |
Determination of Cypermethrin and Its Toxico-kinetics in Rats |
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| SONG Ya-juan,DING Guo-hua,LIU Yang,SUN Jie-wen,LIU Da-yang. Determination of Cypermethrin and Its Toxico-kinetics in Rats[J]. Industrial Health and Occupational Diseases, 2010, 0(1) |
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| Authors: | SONG Ya-juan DING Guo-hua LIU Yang SUN Jie-wen LIU Da-yang |
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| Affiliation: | Heilongjiang Provincial Academy of Traditional Medicine;Harbin 150036 China |
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| Abstract: | Objective To develop a determination method for cypermethrin in rat plasma and tissues,and to study its toxico-kinetics in rats.Methods The blood and tissues samples were collected on times after bolus iv administration 2 mg/kg cypermethrin to rats.GC-ECD method was used to determine the concentration of cypermethrin in plasma and tissues.Time-course and toxico-kinetics parameters of cypermethrin in plasma were analyzed.Results Cypermethrin showed two compartment models in rats and the main parameters of to... |
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| Keywords: | Cypermethrin Plasma Tissue GC-ECD Toxico-kinetics |
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