| 药物性牙龈增生发病机制的研究进展 |
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| 引用本文： | 黄雅玲,李升,杨明华. 药物性牙龈增生发病机制的研究进展[J]. 国际口腔医学杂志, 2008, 35(4) |
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| 作者姓名： | 黄雅玲 李升 杨明华 |
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| 作者单位： | 1. 南京大学医学院附属口腔医院牙周科,江苏,南京,210008
2. 井冈山大学医学院口腔医学教研室,江西,吉安,343000 |
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| 摘 要： | 药物性牙龈增生是指服用抗癫痫药、钙通道阻滞剂和免疫抑制剂等某些特定药物引起的牙龈增生和体积增大,具有共同的病理组织学特点,其发病机制目前仍无定论。下面就药物性牙龈增生在胶原的合成与降解失衡、上皮细胞的增殖和程序性细胞死亡以及上皮下炎症浸润机制上取得的研究进展作一综述。
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| 关 键 词： | 药物性牙龈增生 胶原 程序性细胞死亡 炎症 硝苯地平 苯妥英钠 环孢素 |
Progress in research on the pathogenesis of drug-induced gingival overgrowth |
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| HUANG Ya-ling,LI Sheng,YANG Ming-hua. Progress in research on the pathogenesis of drug-induced gingival overgrowth[J]. Journal of International Stomatology, 2008, 35(4) |
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| Authors: | HUANG Ya-ling LI Sheng YANG Ming-hua |
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| Abstract: | Drug-induced gingival overgrowth(DGO) is the gingival hyperplasia and volume enlargement, a side effect associated with 3 types of drugs: anticonvulsants, calcium channel blockers and immunosuppressive agents. It is characterized by some common pathological features. However, the mechanisms of these disorders have not been elucidated. This review focuses on the progress in research on the pathogenesis of DGO at 3 aspects: disruption of homeostasis of collagen synthesis and degradation, imbalance of proliferation and apoptosis of epithelial cell and subepidermal inflammation. |
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| Keywords: | drug-induced gingival overgrowth collagen apoptosis inflammation nifedipine phenytoin cyclosporin A |
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