阿奇霉素固体分散体制备工艺研究

目的比较不同方法制备难溶性阿奇霉素固体分散体的体外溶出度,优化制备工艺。方法选择不同载体,并采用热熔挤出法和喷雾干燥法制备阿奇霉素固体分散体,并与气流粉碎技术制备的样品比较。采用饱和溶解度和体外累积溶出度判定不同方法所制备成品的差异。结果 2种固体分散体制备技术均能加快药物的溶出度,同时均优于气流粉碎制备的样品。结论相比热熔挤出法,采用喷雾干燥法制备的固体分散体更能显著提高药物的饱和溶解度和溶出度。

Technologies in the Preparation of Azithromycin Solid Dispersion

Objective To compare the dissolution in vitro in different technologies of preparing azithromycin solid dispersion and optimize the preparation technique. Methods Different carriers were selected,and the solid dispersion of azithromycin was respectively prepared by using melting extrusion and spray dehydration techniques,and then compared with samples prepared by airflow crushing technique. Properties of the solid dispersion prepared by different methods were compared using saturated solubility and cumulative dissolution in vitro. Results Both solid dispersion preparation techniques could accelerate the dissolution rate of the drug and were superior to the samples prepared by airflow crushing technique. Conclusion Compared with melting extrusion,the solid dispersion prepared by spray dehydration can significantly improve the saturated solubility and dissolution of the drug.