Hormonal contraceptive use, pregnancy and parity, and the risk of cervical intraepithelial neoplasia 3 among oncogenic HPV DNA-positive women with equivocal or mildly abnormal cytology |
| |
Authors: | Castle Philip E Walker Joan L Schiffman Mark Wheeler Cosette M |
| |
Institution: | Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA. castlep@mail.nih.gov |
| |
Abstract: | Oral contraceptive (OC) use, hormonal contraceptive use and multiparity are potential risk factors for cervical precancer, cervical intraepithelial neoplasia 3 (CIN3), but a limited number of studies have adequately accounted for possible confounding effect of oncogenic human papillomavirus (HPV) infection. To examine the relationships of these factors with CIN3, we conducted an analysis of women (n = 5,060) with minimally abnormal Pap smears who were enrolled in the ASCUS and LSIL Triage Study (ALTS), a clinical trial to evaluate management strategies. Cervical specimens collected at enrollment were tested for HPV DNA using 2 methods. Multivariate logistics regression models were used to assess associations (odds ratio OR] with 95% confidence intervals CI]) of the potential risk factors (e.g., OC use and parity) with testing oncogenic HPV positive among controls (
|
| |
Keywords: | cervical intraepithelial neoplasia human papillomavirus (HPV) triage cofactors hormonal contraceptive use pregnancy parity |
本文献已被 PubMed 等数据库收录! |
|