| 盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨 |
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| 引用本文： | 张瑛,张钧寿,陈国广,张芳,王猛.盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨[J].中国药科大学学报,2002,33(3):42-44. |
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| 作者姓名： | 张瑛 张钧寿 陈国广 张芳 王猛 |
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| 作者单位： | 中国药科大学药剂学教研室,南京,210009 |
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| 摘 要： | 目的：探索固体自乳化释放药系统，研制自乳化缓释片，考察体外释药行为。方法：以盐酸维拉帕米（Verpamil Hydrochloride,VH)为模型药物，以吐温80（Tween80），豆磷脂（sbpc)为乳化剂，以羟丙甲纤维素（HPMC），卡波普（carbopol)为骨架材料，制备自乳化缓释片。结果：以含吐温80和豆磷脂10％，羟丙甲纤维素和卡波普30％的处方乳化效果好，体外释药符合要求。结论：通过调节乳化剂和骨架材料的比例，可以获得理想的自乳化固体缓释制剂。
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| 关 键 词： | 自乳化药物传递系统 缓释片 盐酸维拉帕米 |
| 文章编号： | 1000-5048(2002)03-0208-03 |
Development of Verapamil Hydrochloride Self-Emulsifying Sustained-Release Tablets and Exploration of Released Character |
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| ZHANG Ying,ZHANG Jun Shou,CHEN Guo Guang,ZHANG Fang,WANG Meng.Development of Verapamil Hydrochloride Self-Emulsifying Sustained-Release Tablets and Exploration of Released Character[J].Journal of China Pharmaceutical University,2002,33(3):42-44. |
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| Authors: | ZHANG Ying ZHANG Jun Shou CHEN Guo Guang ZHANG Fang WANG Meng |
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| Institution: | ZHANG Ying,ZHANG Jun Shou,CHEN Guo Guang,ZHANG Fang,WANG Meng Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | AIM Self emulsifying drug delivery systems were studied. Verapamil Hydrochloride self emulsifying sustained release tablets were developed and evaluated \%in vitro\% release characteristics. METHODS The Verapamil Hydrochloride formulations were screened according to the designed \%in vitro\% release rate by the use of Tween80, Sbpc as emulsifier and HPMC, and carbopol as the gel matrix. RESULTS The self emulsifying sustained release tablets prepared containing 10% emulsifier and 30% gel matrix were preferable. CONCLUSION Adjusting the ingredients of formulation may obtain the desirable self emulsifying sustained release tablets. |
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| Keywords: | Self emulsifying drug delivery systems (SEDDS) Sustained release tablets Verapamil hydrochloride |
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