子宫内膜不典型增生的保守治疗

目的：探讨孕激素治疗子宫内膜不典型增生（EAH）的疗效及治疗前后子宫内膜雌激素受体和孕激素受体（ER、PR）的变化情况。方法：对32例经诊刮病理确诊为EAH需保守治疗的患者采取孕激素治疗，每3个月为一疗程，疗程结束后了解其子宫内膜病变病检逆转情况和治疗前后ER、PR的变化。结果：一疗程结束后总治愈率为71．9％（23／32），其中轻度为100％（10／10），中度为61．50％（8／10），重度为55．6％（5／9）。延长疗程，治愈率为100％。治疗前后ER、PR表达下降非常显著（P〈0．01）。结论：对需保留生育功能的子宫内膜不典型增生的患者，在随诊条件下孕激素治疗有一定的效果。

Progestogen Therapy of Atypical Hyperplasia of Endometrium

Objective:To approach curative effect of progestogen in curing atypical hyperplasia of endometrium and to determine the change of estrogen receptor and progesterone receptor comparing with pretherapy.Methods: Thirty-two patients finally diagnosised as EAH by diagnostic curettage were treated with pregnancy hormone,three months was one course of treatment,and the retroconversion of endometrium and the change of estrogen receptor and progesterone receptor were determined.Results: Assembly cure rate was 71.9%(23/32) after one course of treatment,among them light degree was 100%(10/10),midrange was 61.50%(8/10),weight degree was 55.6%(5/19).If lengthen the course of treatment the cure rate was 100%,after treatment.the expression of estrogen receptor and progesterone receptor decreased significantly(P<0.01).Conclusion: The pregnancy hormone therapy is safe and effective on condition of Follow-Up for the patients of remaining potentia generandi.