Recombinant human growth hormone treatment of children on hemodialysis |
| |
Authors: | Etienne Bérard Hélène Crosnier Anne Six-Beneton Thierry Chevallier Pierre Cochat Michel Broyer |
| |
Institution: | Service de Pédiatrie, CHU de Nice, Nice, France, FR Département de Pédiatrie, H?pital Necker-Enfants Malades, Paris, France, FR Service de Néphrologie Pédiatrique, CHU de Lyon, Lyon, France, FR Département d’Information Médicale, CHU de Nice, Nice, France, FR
|
| |
Abstract: | Forty-two children, aged 2–21.5 years on hemodialysis with a height below –2.0 standard deviation score (SDS) for age, were
selected to receive recombinant human growth hormone (rhGH) therapy at 17 French centers. Of the 42 children, 36 were prepubertal
and 8 were in early puberty (testicular volume between 4 and 8 ml for boys, breast development B2 or B3 in girls). All received
1 IU/kg per week by daily subcutaneous injection for 1–5 years. The year before rhGH therapy served as a control period. During
the 1st year of treatment, mean growth velocity increased from 3.5 to 7.0 cm/year (P <0.0001) and was always over 2.5 cm/year. This velocity allowed a catch-up growth of +0.5 height SDS. Neither weight nor
the body mass index varied compared with the pretreatment year. No change was observed in urea, creatinine, or glucose tolerance.
The mean increment in bone age was 0.9 years. The mean growth velocity decreased over subsequent years (P <0.0001), but remained higher than the prestudy velocity. A significant negative correlation was observed during the 1st
year between the increase in growth velocity and the prestudy velocity (P <0.0001), with the least gain in patients who had the best spontaneous velocity. Pubertal status had no influence on response
to rhGH. No significant side effects were observed during the 103 treatment-years. Five patients developed secondary hyperparathyroidism
and 1 suffered from acute pancreatitis, but the relationship with rhGH therapy remains uncertain. rhGH therapy appears indicated
for children on hemodialysis, even though the potential benefits appear somewhat lower for those with a spontaneous growth
velocity over 6 cm/year.
Received April 18, 1997; received in revised form October 23, 1997; accepted October 28, 1997 |
| |
Keywords: | : Hemodialysis Growth Growth hormone treatment |
本文献已被 SpringerLink 等数据库收录! |
|