子宫腺肌病患者内膜中热休克蛋白70的表达

目的　探讨子宫腺肌病患者在位及异位内膜中热休克蛋白70的表达及其在子宫腺肌病发病中的作用。方法　采用免疫组化链霉菌抗生物素蛋白-过氧化物酶染色法(SP法)检测子宫腺肌病患者在位及异位内膜各32例、子宫肌瘤内膜30例及正常内膜2 0例中HSP 70表达水平。结果　免疫组化显示子宫腺肌病患者在位及异位内膜组织中HSP70表达水平显著高于子宫肌瘤内膜(P<0 .0 1 )及正常内膜(P<0 .0 0 1 ) ,异位内膜中的表达高于在位内膜(P<0 .0 5 ) ,并且失去在正常内膜组织中的周期性变化。结论　HSP 70在在位及异位内膜组织中的高表达,可能与子宫腺肌病的发病有关。

Expression of heat shock protein 70 in eutopic and ectopic endometrium in adenomyosis

Objective To evaluate the expression of heat shock protein 70( HSP70) in eutopic and ectopic endometrium of adenomyosis (AM) and to explore the roles of HSP70 in the pathogenesis of AM. Methods 32 samples of eutopic and ectopic endometrium of AM, 30 samples of myoma of uterus and 20 samples of normal endomemetrium were examined for HSP70 expression using the immunohistochemical S-P method and computerized imaging analysis system. Results The expression of HSP70 in ectopic endometrium of AM was notably higher than that in myoma of uterus and normal endomemetrium (both P<0.01). The expression was also higher than that in eutopic endometrium(P<0.05). The expression of HSP70 in ectopic and eutopic endometrium of AM did not relate to the phase of menstrual cycle, namely there was no obvious correlation between the phase and HSP70 expression levels(P>0.05).Conclusion HSP70 is overexpressed in AM, which may be correlated with the pathogenesis of this disease.