肾病综合征医院感染危险因素探讨及防治措施

目的 探讨儿童原发性肾病综合征（肾病）医院感染的危险因素及其防治措施。方法 收集１９０例１９９１～１９９９年肾病患儿住院病例，采用单因素分析及Ｌｏｇｉｓｔｉｃ多因素回归模型回顾性分析各危险因素的分布。结果 肾病医院感染发生率３４．２％（６５／１９０），其中呼吸道感染占６９．７％。单因素分析危险因素为２４ｈ每公斤体重尿蛋白定量（尿蛋白）、住院时间、激素使用时间、抗生素使用种数及时间。多因素分析危险为

Risk factors and prevention and treatment for nosocomial infection in the children with nephrotic syndrome

Objective To discuss the risk factors for nosocomial infection in the children with nephrotic syndrome (NS) and their prevention. Methods Collecting 190 history data of the children with NS from 1991 to 1999. Using single factor analysis and multivariate stepwise regression for analyzing retrospectively the risk factors. Results The ratio of nosocomial infection was 34.2%(65/190). Respiratory tract infection accounted for 69.7%. The single factor analysis showed that the risk factors for nosocomail infection in the children with NS were urine protein quantity per kg per 24 h (UPR) ,time of hospitalization ,time of using steroid , type of using antibiotics and time of antibiotics. Multiple factor analysis showed that the UPR, type of using antibiotics and time of antibiotics were the risk factors. Conclusion The important methods to reduce the radio of nosocomail infection are to reinforce management of respiratory diseases ,establish purified ware and use antibiotics reasonably . Once the diagnosis of NS is determined,the steroid should be used by enough quantity and for enough time in order to reduce loss of protein from the urine as soon as possible.