| 谷氨酰胺对非甾体抗炎药损伤胃黏膜的保护作用 |
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| 引用本文： | 张宏伟,张志广.谷氨酰胺对非甾体抗炎药损伤胃黏膜的保护作用[J].医学综述,2010,16(1). |
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| 作者姓名： | 张宏伟 张志广 |
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| 作者单位： | 1. 天津市儿童医院消化科,天津,300074
2. 天津医科大学第二医院消化科,天津,300211 |
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| 摘 要： | 谷氨酰胺能促进内源性前列腺素的合成、抑制炎性细胞因子分泌,减轻炎症损伤、增强胃黏膜抗氧自由基损伤的能力、增强胃黏膜黏液层屏障功能、抑制细胞凋亡、调节免疫应答、参与消化道黏膜细胞修复。因此,谷氨酰胺能使损伤的胃黏膜上皮修复、使黏膜下组织结构修复和重建,从而促进在使用非甾体抗炎药后而损伤的胃黏膜的恢复。通过对非甾体抗炎药损伤胃黏膜后谷氨酰胺所起的保护作用的研究,有助于改进临床治疗策略。
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| 关 键 词： | 谷氨酰胺 胃黏膜 非甾体抗炎药 |
The Protective Effect of Glutamine on the Gastric Mucosal Damage by Non-steroidal Anti-inflammatory Drug |
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| ZHANG Hong-wei,ZHANG Zhi-guang.The Protective Effect of Glutamine on the Gastric Mucosal Damage by Non-steroidal Anti-inflammatory Drug[J].Medical Recapitulate,2010,16(1). |
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| Authors: | ZHANG Hong-wei ZHANG Zhi-guang |
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| Institution: | ZHANG Hong-wei1,ZHANG Zhi-guang2.(1.Department of Gastroenterology,Tianjin Children\'s Hospital,Tianjin 300074,China,2.Department of Gastroenterology,the Second Hospital of Tianjin Medical Univercity,Tianjin 300211,China) |
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| Abstract: | Glutamine can promotes the synthesis of endogenous prostaglandins,inhibit secretion of inflammatory cytokines,reducing inflammation,strengthen the capacity of gastric mucosal to oppose oxidant free radical,enhance the barrier function of gastric mucus slime layer,inhibit apoptosis,regulation immune response and involved cytothesis of digestive tract mucosa.It's effects are to repair the lesion of gastric mucosal epithelium and to restore and remodel the constructions of submucous.It can improve the healing ... |
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| Keywords: | Glutamine Gastric Mucosa Non-steroidal anti-inflammatory drug |
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