CIK细胞免疫治疗对转移性肾细胞癌患者免疫功能的影响 |
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引用本文: | 崔洪泉,;赵俊峰,;李保东,;张林超. CIK细胞免疫治疗对转移性肾细胞癌患者免疫功能的影响[J]. 中国现代医生, 2014, 0(29): 132-133 |
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作者姓名: | 崔洪泉, 赵俊峰, 李保东, 张林超 |
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作者单位: | [1]河南省中医院泌尿外科,河南郑州450002; [2]河南省肿瘤医院泌尿外科,河南郑州450008; [3]郑州市中心医院泌尿外科,河南郑州450000 |
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摘 要: | 目的:观察CIK细胞免疫治疗对转移性肾癌患者免疫功能的影响。方法选取2010-2012年收治的转移性肾癌患者,在常规治疗措施的基础上联合应用CIK细胞免疫方法进行临床治疗,治疗3个疗程后,监测治疗前后CD3+、CD4+、CD8+、CD4+/CD8+比值等免疫功能指标,进行统计学分析。结果治疗后患者外周血中CD3+、CD4+、CD8+、CD4+/CD8+水平优于治疗前(P〈0.055)。结论采用悦陨运细胞免疫治疗能有效提高转移性肾癌患者的免疫功能。
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关 键 词: | CIK细胞 转移性肾细胞癌 免疫功能 |
Effect of CIK cells immunotherapy on immunological function of patients with metastatic renal cell carcinoma |
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Affiliation: | CUI Hongquan, ZHAO Junfeng, LI Baodong, ZHANG Linchao (1.Department of Urology, Traditional Chinese Medicine Hospital of Henan Province, Zhengzhou 450002,China;2.Department of Urology, Cancer Hospital of Henan Province, Zhengzhou 450008, China; 3.Department of Urology, Cen- tral Hospital of Zhengzhou City, Zhengzhou 450000, China) |
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Abstract: | Objective To study the effect of cytokine-induced killer(CIK) cells immunotherapy on immunological func-tion of patients with metastatic renal cell carcinoma.Methods A total of 70 patients with metastatic renal cell carcino-ma were randomly divided into 2 groups, 35 cases of the treatment group were added with CIK cells, while the control group was given IL-2 and IFN-α, detected the immunological function of 70 cases including the levels of CD3+, CD4+, CD8+T cells, ratio of CD4+/CD8+, one week before therapy of CIK cells and one month week after treatment. Results The levels of CD3+、CD4+cells, ratio of CD4+/CD8+in peripheral blood of patients with renal cancer of two groups were much higher than those before therapy (P〈0.05), the levels CD8+ was lower after treatment, there were significant changes (P〈0.05). Conclusion CIK cells immunotherapy can enhance the immunological function of patients with meta-static renal cell carcinoma. |
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Keywords: | CIK cells Metastatic renal cell carcinoma Immunological function |
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