热灌注化疗治疗卵巢癌合并腹腔积液疗效观察

目的：观察临床中卵巢癌合并腹腔积液患者应用热灌注化疗的临床疗效。方法选取我院2006年1月-2013年1月期间40例卵巢癌合并腹腔积液患者为研究对象，按照随机数字法分为研究组和对照组各20例。所有病例都曾经手术治疗，病理确诊为上皮性卵巢癌，均行术后化疗，肿瘤未控或复发，合并腹腔积液。对照组给予常规全身化疗，研究组给予腹腔热灌注化疗联合全身化疗，观察两组临床疗效。结果研究组治疗有效率和生活质量评分均明显高于对照组（P〈0.05），差异有统计学意义；两组患者均未发生严重的毒副反应，出现毒副反应较轻，均对症处理后缓解。研究组1年生存率为85.0%，对照组为65.0%，差异有统计学意义（P〈0.05）。结论对于卵巢癌合并腹腔积液患者给予热灌注化疗治疗是可行的，能有效提高临床疗效与生活质量，值得临床应用。

Efficacy observation of chemohyperthermia in treatment of ovarian can-cer combined with peritoneal effusion

Objective To observe the clinical efficacy of chemohyperthermia in the treatment of ovarian cancer com-bined with peritoneal effusion. Methods Forty patients with ovarian cancer combined with peritoneal effusion treated in our hospital from January 2006 to January 2013 were selected as the study subjects and randomly divided into the study group and the control group according to the random number method, with 20 patients in each group. All the pa-tients once went through surgical treatment, were diagnosed with epithelial ovarian cancer, received postoperative chemotherapy, had uncontrolled or recurrent tumor, and were complicated by peritoneal effusion. The control group was given conventional whole body chemotherapy and the study group was given intraperitoneal chemohyperthermia com-bined with whole body chemotherapy. The clinical efficacy of the two groups was observed. Results The study group had significantly higher treatment effective rate and life quality score than the control group （P〈0.05）, with statistical significance. Neither group had severe toxic nor side reactions; The existing toxic and side reactions were mild and re-mitted after symptomatic treatment. The 1-year survival rate of the study group was 85.0%and that of the control group was 65.0%. The study group had significantly higher 1-year survival rate than the control group（P〈0.05）, with statistical significance. Conclusion It is feasible to provide chemohyperthermia to the patients with ovarian cancer combined with peritoneal effusion and it can effectively improve the clinical efficacy and life quality, which is worthy of clinical appli-cation.