水蛭通胶囊治疗老年脑血管性痴呆的临床研究

目的 观察水蛭通胶囊治疗老年脑血管性痴呆(vascular dementia，VD)患者的临床疗效及相关理化指标的变化。方法 85例老年VD患者按3：2比例分为两组。治疗组5l例，采用水蛭通胶囊治疗，对照组34例给予脑复康治疗。治疗前后进行张氏痴呆修改量表(HDS)、社会活动功能量表(FAQ)评分，并采用DHZ-200型智能血流分析仪进行脑血流检测及血液流变学等检查。结果 水蛭通胶囊能显著改善VD患者临床症状和颅内血流动力学状态及血液的高黏、高凝、高聚状态，提高部分患者的生活能力，降低全血黏度和血浆比黏度，治疗前后比较差异均有显著性(P<0．05)。结论 水蛭通胶囊治疗老年脑血管性痴呆疗效肯定。

Clinical Study of Shuizhitong Capsule in Treating Senile Vascular Dementia

Objective To observe the clinical therapeutic effect of Shuizhitong capsule (SZT) in treating senile vascular dementia (VD) and on changes of related physio chemical criteria. Methods Eighty five patients with VD were randomly divided into the treated group (n=51) and the control group (n=34) in the ratio of 3:2, treated with SZT and Piracetam respectively. Before and after treatment, the Zhang's Dementia Scoring (HDS) and Function of Social Activity Questionnaire (FAQ) scoring, cerebral blood flow and hemorrheologic properties were determined. Results SZT could significantly improve the patients' clinical symptoms, intracranial hemodynamic condition and the hyperviscosity, hypercoagulation and hyperaggregation status, lower the whole blood and plasma specific viscosity, raise the living standard of partial patients, with significant difference between before and after treatment (P<0 05). Conclusion The therapeutic effect of SZT in treating senile VD is definite.