Characteristic signal changes in the pontine base on T2- and multishot diffusion-weighted images in spinocerebellar ataxia type 1 |
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Authors: | M Adachi T Kawanami H Ohshima T Hosoya |
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Institution: | (1) Department of Radiology of Ohshima Clinic, 1-14 Yonchyome, Sakurada Nishi, Yamagata 990-2321, Japan;(2) Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, Japan;(3) Department of Neurology of Ohshima Clinic, 1-14 Yonchyome, Sakurada Nishi, Yamagata 990-2321, Japan;(4) Department of Radiology, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, Japan |
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Abstract: | The aim of the present study was to demonstrate characteristic signal changes of the pontine base on T2-weighted images of
patients with SCA 1, and to elucidate the relationship between abnormal high-intensities of the pontine base on T2-weighted
images and the findings on multishot diffusion-weighted images. We assessed abnormal signals of the pontine base on T2-weighted
images from 50 controls and six patients with SCA 1 diagnosed by genetic analysis. At the same time, we evaluated the degeneration
of the transverse pontine fibers in the pontine base by multishot diffusion-weighted imaging. A midline high-intensity was
seen in the pontine base on T2-weighted images in two of the 50 controls and five of the six patients with SCA 1. The midline
high-intensity had a sensitivity of 83.3% for patients and a specificity of 96.0% for controls. Multishot diffusion-weighted
imaging demonstrated the degeneration—the amorphous-pattern signal—of the transverse pontine fibers in four (66.7%) of the
six patients. In the other two patients, the zebra-pattern signal was seen in the pontine base. The midline high-intensity
on T2-weighted images appears to be one of characteristic MRI findings of SCA 1. Multishot diffusion-weighted imaging suggested
that the midline high-intensity should reflect the degeneration of the transverse pontine fibers. |
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Keywords: | Spinocerebellar degeneration (SCD) Spinocerebellar ataxia type 1 (SCA 1) Brain stem Transverse pontine fiber MRI T2-weighted image Diffusion-weighted image |
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