Off-Line Fractional Exhaled Nitric Oxide Measurement Is Useful to Screen Allergic Airway Inflammation in an Adult Population |
| |
| Authors: | Junpei Saito Suguru Sato Hideki Hasunuma Yasushi Ishimaru Hiroshi Kanegae Shoji Kudo |
| |
| Affiliation: | 1. Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan;2. Center for Environmental Information Science, Tokyo, Japan;3. Fourth Department of Internal Medicine, Nippon Medical University, Tokyo, Japan |
| |
| Abstract: | To determine whether off-line fractional exhaled nitric oxide (FeNO) measurement is applicable to screen allergic airway inflammation for epidemiologic studies, we examined 280 adults, measuring off-line FeNO samplings, pulmonary function, and serum immunoglobulin E (IgE). Subjects with recurrent wheeze (recurrent wheezers) had significantly higher FeNO and IgE levels and significantly lower forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) than non-wheezers. Statistical analysis showed that FeNO and FEV1/FVC were significant predictors for recurrent wheezers, independent of smoking. The cut-off FeNO level for screening allergic airway inflammation was 38 ppb in non-smokers and 32.9 ppb in smokers. Thus, off-line FeNO can be used as a good marker to screen allergic airway inflammation, regardless of smoking. |
| |
| Keywords: | fractional exhaled nitric oxide off-line measurement wheeze epidemiological screening asthma |
|
|
