寄生虫感染与“卫生假说”关系研究进展

近年来,许多发达国家感染性疾病发病率不断下降,但自身免疫性疾病和过敏性哮喘发病率呈逐年上升趋势。"卫生假说"的提出为基于寄生虫感染治疗自身免疫性疾病和过敏性哮喘提供了新思路。大量流行病学和动物实验数据均显示,寄生虫感染能有效抑制糖尿病、多发性硬化症、炎症性肠病、类风湿性关节炎、过敏性哮喘等疾病发生。寄生虫感染和"卫生假说"间存在复杂的潜在机制,其中调节性T(Treg)细胞和Th17细胞的各自作用和相互调节逐渐成为研究热点。本文阐述了寄生虫感染与"卫生假说"关系研究进展,并简要概述Treg细胞和Th17细胞在其中的作用。

Relationship between parasitic infections and hygiene hypothesis: a review

Recently, the incidence of infectious diseases continues to decline in many developed countries; however, the incidence of autoimmune diseases and allergic asthma appears a tendency towards a rise over years. “Hygiene hypothesis” provides new insights into the treatment of autoimmune disorders and allergic diseases based on parasitic infections. Increasing evidence shows that parasitic infections may effectively inhibit the development of diabetes, multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis and allergic asthma. There are complex mechanisms underlying the relationship between parasitic infections and “hygiene hypothesis”, among which regulatory T (Treg) cells and Th17 cells are becoming a hot topic of research. This paper reviews the progresses in the research on the relationship between parasitic infections and “hygiene hypothesis”, and summarizes the roles of Treg cells and Th17 cells in the interplay between parasitic infections and “hygiene hypothesis”.