还原型谷胱甘肽联合甲巯咪唑治疗甲亢的临床观察

目的:观察还原型谷胱甘肽联合甲巯咪唑治疗甲亢的临床疗效,及对患者外周血清炎症因子的影响。方法:108例甲状腺功能亢进患者随机分为对照组和观察组,每组54例。两组患者均接受甲巯咪唑治疗,观察组同时联合还原型谷胱甘肽治疗;疗程均为2周。比较两组患者治疗前后总三碘甲状腺氨酸(TT3)、总甲状腺素(TT4)、血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)以及炎症因子白细胞介素2(IL-2)、白细胞介素6(IL-6)水平变化,评价两组临床疗效以及药品不良反应发生情况。结果:两组患者治疗后TT3、TT4、FT3、FT4水平以及血清IL-2、IL-6水平均较治疗前下降,TSH水平均较治疗前升高(P<0.05);且观察组TT3、TT4、FT3、FT4水平和血清IL-2、IL-6水平显著低于对照组,TSH水平高于对照组(P<0.05)。观察组治疗总有效率明显高于对照组(P<0.05);两组药品不良反应发生率差异无统计学意义(P>0.05)。结论:还原型谷胱甘肽联合甲巯咪唑治疗甲状腺功能亢进症效果优于甲巯咪唑单一治疗,且不增加药品不良反应,可能与还原型谷胱甘肽降低机体自身免疫反应相关。

Clinical Therapeutic Effect of Reduced Glutathione Combined with Methimazole in the Treatment of Hyperthyroidism

Objective:To observe the clinical therapeutic effect of reduced glutathione combined with methimazole on hyperthyroidism and the influence on peripheral inflammatory factors.Methods:Totally 108 cases of hyperthyroidism admitted to our department from September 2014 to September 2017 were randomly divided into the control group and the observation group according to the order of admission with 54 cases in each group.All the subjects received methimazole treatment,and the observation group was treated with reduced glutathione additionally.The levels of TT3(total T3),TT4(total T4),FT3(free three iedine),FT4(free thyroid hormone),TSH(thyroid stimulating hormone)and inflammatory factors IL-2(Interleukin-2)and IL-6(Interleukin-6)in the two groups were analyzed statistically.Results:The levels of TT3,TT4,FT3 and FT4 in the two groups were lower than those before the treatment.The level of TSH was higher than that before the treatment.The levels of TT3,TT4,FT3 and FT4 in the observation group were lower than those in the control group,while the level of TSH was higher than that in the control group(P<0.05).At the same time,the levels of serum inflammatory factors IL-2 and IL-6 in the two groups were lower than those before the treatment,and the observation group had a greater decrease than the control group(P<0.05).There was no significant difference in adverse reactions between the groups(P>0.05).Conclusion:The effect of reduced glutathione combined with methimazole in the treatment of hyperthyroidism is better than that of methimazole alone,which may be related to the reduction of autoimmune response of reduced glutathione.