炮制对三七化学成分及药理作用影响的研究进展

三七作为我国一种名贵中药材,具有散瘀止血、消肿定痛、补益气血之功效,是传统的活血化瘀药。三七经过炮制加工后,功效明显不同,生品主散瘀止血,熟品主补血益气。近年来对三七的研究逐渐深入,主要研究方向为生三七的化学成分、药理作用及临床应用等,对熟三七的研究虽逐年增加,但炮制机制及药效物质基础变化尚不明确。该文对三七现代炮制方法进行了较为系统的整理,对比了三七炮制前后的化学成分变化及药理作用差异,提出应用现代科学技术研究三七物质转化规律与补血作用的相关性,以期阐释其炮制机制,提升三七饮片的质量评价体系,为该饮片临床用药的安全性和有效性提供保障。

Progress in Research on Effect of Processing on Chemical Constituents and Pharmacological Effect of Notoginseng Radix et Rhizoma

Notoginseng Radix et Rhizoma, one of precious and important traditional Chinese medicinal herb, has the functions of dispersing blood stasis and stopping bleeding, detaching swelling and alleviating pain, and invigorating Qi and blood. It is a traditional Chinese medicine for promoting blood circulation and removing blood stasis. After processing, the efficacy of Notoginseng Radix et Rhizoma was obviously different, the raw products mainly dispersed blood stasis and hemostasis, while the main effect of processed products was to replenish blood and Qi. In recent years, more attention has been paid to Notoginseng Radix et Rhizoma research, mainly focusing on the chemical constituent, pharmacological action and clinical application of the raw products. Although the research on processed Notoginseng Radix et Rhizoma has been increasing in these years, the mechanism of processing and the changes of bioactive constituents before and after processing are still unclear. This paper systematically summarized the modern processing methods of Notoginseng Radix et Rhizoma and compared the changes in chemical constituent and pharmacological action before and after processing through literature search. It is proposed that modern technologies should be put forward to study the correlation between the chemical constituent transformation and enriching blood as the breakthrough point, in order to explain the processing mechanism of Notoginseng Radix et Rhizoma, improve the quality evaluation system of this decoction pieces, and provide guarantee for the safety and effectiveness of its clinical medication.