| 大鼠角膜移植戊巴比妥腹腔注射联用利多卡因球后注射麻醉的效果 |
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| 引用本文： | 张研,陆晓和,李祥. 大鼠角膜移植戊巴比妥腹腔注射联用利多卡因球后注射麻醉的效果[J]. 国际眼科杂志, 2009, 9(5): 853-855. DOI: 10.3969/j.issn.1672-5123.2009.05.014 |
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| 作者姓名： | 张研 陆晓和 李祥 |
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| 作者单位： | 1. 南方医科大学,原第一军医大学,附属珠江医院眼科,中国广东省广州市,510282
2. 南方医科大学南方医院药学部,中国广东省广州市,510515 |
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| 摘 要： | 目的:探讨大鼠穿透性角膜移植手术戊巴比妥腹腔注射与利多卡因球后注射联合应用的麻醉效果。方法:SPF级雌性SD大鼠158眼行同种异体穿透性角膜移植术,先以戊巴比妥2mL/kgip麻醉,然后向术眼肌锥内注射20g/L利多卡因0.02～0.08mL,观察麻醉效果及并发症。麻醉效果分为满意、比较满意和不满意3级并观察并发症虹膜刺激、晶状体脱失、眼球穿破和眼睑麻痹的发生,作为麻醉效果的辅助指标。结果:因大鼠术中死亡或无法继续观察剔除统计范围7例。在手术成功151例中麻醉效果满意120例(79.5%),比较满意18例(11.9%),不满意13例(8.6%),总体效果满意。戊巴比妥最佳剂量为1.5～2mL/kg;利多卡因球后注射每眼0.03～0.04mL,麻醉时间约60min。有30(19.9%),5(3.3%),9(6.0%)和9(6.0%)例出现虹膜刺激、眼球穿破、眼睑麻痹和晶状体脱失。结论:大鼠穿透性角膜移植术戊巴比妥全身麻醉与利多卡因球后麻醉联合应用效果满意和基本满意,大鼠死亡率低。
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| 关 键 词： | 大鼠 同种异体穿透性角膜移植 利多卡因 球后注射 |
Combined anesthesia effect of pentobarbital peritoneal cavities injection and lidocaine retrobulbar injection in rat penetrating keratoplasty |
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| Yan Zhang,Xiao-He Lu,Xiang Li. Combined anesthesia effect of pentobarbital peritoneal cavities injection and lidocaine retrobulbar injection in rat penetrating keratoplasty[J]. International Eye Science, 2009, 9(5): 853-855. DOI: 10.3969/j.issn.1672-5123.2009.05.014 |
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| Authors: | Yan Zhang Xiao-He Lu Xiang Li |
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| Affiliation: | Yan Zhang1,Xiao-He Lu1,Xiang Li21Department of Ophthalmology,Zhujiang Hospital Affitiated to Southern Medical University,Guangzhou 510282,Guangdong Province,China,2Department of Pharmacy,Nanfang Hospital,Southern Medical University,Guangzhou 510515 |
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| Abstract: | AIM:To discuss the combined effect of lidocaine retrobulbar anesthesia and pentobarbital general anesthesia in rat penetrating keratoplasty. METHODS:Complete 158 allergenic penetrating keratoplasty successfully on female SPF SD rats. Firstly inject 30g/L pentobarbital 0.1-0.2mL per 100g weight into rats’ peritoneal cavities then 20g/L lidocaine 0.02-0.08mL retrobulbar, observe anesthesia effect and complications. Divide anesthesia effect into three grades: satisfied, relatively satisfied and not satisfied. Complications including iris stimulation, lens deletion, eyeball perforation and blepharoplegia were taken as assistant indexes for evaluating anesthesia effect. RESULTS:Among seven in 158 cases were excluded because rats died during operation or not be able to observe continuously. Among the rest 151 cases 120 had satisfied anesthesia effect (79.5%), 18 cases were relatively satisfied (11.9%) and 13 were not satisfied (8.6%). Anesthesia effect was satisfied in total. Pentobarbital dose was 0.15-0.2mL per 100g weight and lidocaine was 0.03-0.04mL per eye, anesthesia time lasted about 60 minutes. In 151 cases, 30(19.9%),5(3.3%),9(6.0%) and 9(6.0%) cases occurred iris stimulation, eyeball perforation, blepharoplegia and lens deletion respectively. CONCLUSION: Lidocaine retrobulbar anesthesia combined pentobarbital general anesthesia was a useful approach in rat penetrating keratoplasty, 91.4% cases had satisfied and relatively satisfied effects. While at the same time, Pentobarbital dose reduced to origin’s 50% and rats’ mortality decreased. |
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| Keywords: | rats penetrating keratoplasty lidocaine retrobulbar injection |
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