SPF级C57BL/6J小鼠生长发育和繁殖性能指标的测定

目的 在SPF级动物饲养条件下，对本中心饲养的SPF级C57BL／6J小鼠生长发育和繁殖性能指标进行测定。方法 挑选80～90日龄C57BL／6J小鼠40只（雌、雄各半），采取1：1间歇同居，兄妹近交繁殖，并统计其生长发育和繁殖性能参数指标。结论 SPF级C57BL／6J小鼠离乳后体重增长较慢；第2、3胎繁殖性能较好，第5胎最差，种鼠连续繁殖5胎后要更换。

Characterization of Growth and Reproductive Performance in SPF C57BL/6J Mice

Objective To characterize the growth and reproductive performance of SPF C57BL/6J mice under SPF raising conditions.Methods 40 seed mice(20 male and 20 female mice,aged 80-90 days)were chosen and monogamously mated(B S).The parameters of growth and reproductive performance were analyzed.Results It was found that SPF C57BL/6J mice were growing slower in development after weaning.The reproductive performance of mice of the second and third birth sequence was best,and that of the fifth birth was the least.Conclusion Our findings indicate that to mate and breed SPF C57BL/6J mice should not be more than 5 births.