阿米洛利超说明书治疗原发性醛固酮增多症合理性的实验研究

目的：研究阿米洛利超说明书用于治疗原发性醛固酮增多症的可行性和安全性等,为其治疗提供合理依据。方法：以植入不同渗透速率含醛固酮微量渗透泵法诱导原发性醛固酮增多症（简称原醛症）大鼠模型为研究对象,灌胃高、中、低剂量的阿米洛利,观察其对大鼠一般行为、血压和心率的影响以及血液和尿液中K^＋、Na^＋的含量变化,并考察阿米洛利超说明书用于原醛症时血液中K^＋、Na^＋含量与醛固酮分泌量之间的关系。结果：模型组尿液中K^＋含量远远高于正常组,而血液中K6^＋含量远远低于正常组;给予盐酸阿米洛利片后,大鼠尿液中K＋含量下降,Na^＋含量升高,血液中K^＋含量上升,Na^＋含量无明显变化;但给予高剂量盐酸阿米洛利片时,血液中的K＋含量显著升高,超过大鼠正常水平。结论：阿米洛利可以超说明书用于治疗原发性醛固酮增多症,但是应严格控制剂量,并随时监测血钾值。

Experimental study on the rationality of amiloride off-label use in treating primary aldosteronism

AIM：To study the feasibility and security of amiloride off-label use in treating primary aldosteronism in order to provide reasonable basis for its treatment.METHODS：Using the primary aldosteronism（short for PA）rat model caused by Mini-Osmotic pump contain aldosterone as the research objects,then given the high,medium and low dose of amiloride for some days.Then observing therapeutical effect and the ADR on PA,and investigating the relationship of aldosterone＇s level and its secrete rate between the amiloride and aldosterone.RESULTS：The content of potassium ion in the urine of model group was far higher than the normal group,but in the blood it was far lower than normal group.After giving amiloride,the content of potassium ion in the urine of rats decreased,the content of sodion increased,while comparing to the indexes in blood,the content of potassium ion increased,and the content of sodion decreased.But white giving high dose of amiloride,the content of potassium ion in the blood increased significantly,which is more than normal rats.CONCLUSION：Amiloride can be offlabel used in treating of primary aldosteronism,but when we give amiloride to patients we should pay much attention to the potassium in patients＇ blood.