复方丹参滴丸治疗高血压患者慢性脑供血不足的临床研究

目的：研究复方丹参滴丸对高血压患者慢性脑供血不足（chronic cerebral circulation insufficiency,CCCI）的临床疗效。方法：选取符合纳入标准的高血压性CCCI患者52例,随机分为治疗组和对照组各26例。两组基础疗法相同,治疗组加用复方丹参滴丸（0.1092g）口服治疗（每日3次,每次10粒）,连续治疗4周,观察临床症状、脑动脉血流速度及血液流变学的变化。结果：治疗组眩晕、头痛、睡眠障碍及其他症状改善的总有效率均显著优于对照组（P〈0.05）。治疗组4周后左椎动脉（LVA）、基底动脉（BA）、右椎动脉（RVA）的收缩期峰值流速（Vs）与舒张期峰值流速（Vd）均明显改善,与对照组比较差异有统计学意义（P〈0.05）。治疗组血液流变学指标明显改善,且显著优于对照组（P〈0.05）。结论：复方丹参滴丸治疗高血压性CCCI疗效显著,值得临床优化与推广。

Clinical research of compound Danshen dripping pills in treating chronic cerebral circulation insufficiency in patients with hypertension

AIM：To explore the therapeutic effect of compound Danshen dripping pills on chronic cerebral circulation insufficiency（CCCI）in patients with hypertension.METHODS：Fifty-two CCCI patients subjected to hypertension were randomly divided into Control and Test groups（n=26）.All patients were received symptomatic treatment,and Test group was given compound Danshen dripping pills orally 3times daily（10pills/time）for 4weeks. Clinlcal symptoms,cerebral arterial flow rate,and hemorheological index were determined. RESULTS：After 4weeks of treatment,the dizziness, headache,dyssomnia and other CCCI symptoms in Test group were significantly reduced compared with Control group（P〈0.05）.The systolic blood flow rate（Vs）and diastolic blood flow rate（Vd）in left vertebral artery（LVA）,basilar artery（BA）,and right vertebral artery（RVA）were all markedly improved in Test group compared with pre-treatment and Control group（P〈0.05）.The hemorheological index in Test group also ameliorated compared with pre-treatment and Control group（P 0.05）. CONCLUSION： Compound Danshen dripping pills is effective to treat CCCI in patients with hypertension and worthy of optimization and generalization.