Secondary Sjögren''s syndrome and chromosome six markers |
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Authors: | R. S. Warlow P. H. Kay J. McCluskey G. Uko R. L. Dawkins |
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Affiliation: | Department of Clinical Immunology, Royal Perth Hospital, Perth, Western Australia |
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Abstract: | Patients with Sj?gren's syndrome (SS) in association with either Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) or Sclerodactyly were tested for HLA-A, B and Dr antigens and the phenotypes of the 4th component of complement (CA). Significant associations were identified between HLA-Bw62, Dr4, C4B2.9, C4A8 and females with SS-RA. The MHC antigen frequencies noted for secondary Sj?gren's syndrome differed from those reported for their respective primary diseases and the implications of these observations are discussed. |
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