缺氧诱导因子-1α与血管内皮生长因子在非小细胞肺癌中的表达及意义

 目的 探讨非小细胞肺癌中缺氧诱导因子-1α（hypoxia-inducible factor 1 alpha，HIF-1α）的表达及其与血管内皮生长因子（vascular endothelial growth factor，VEGF）的关系。方法 采用免疫组织化学方法检测非小细胞肺癌组织中HIF-1α和VEGF的表达。结果 68例非小细胞肺癌组织中HIF-1α和VEGF的表达的阳性率分别为62％和69．1％，20例正常肺组织HIF-1α不表达，VEGF阳性仅2例。HIF-1α和VEGF的表达结果显示：（1）与性别、年龄、病理类型、肿瘤大小无显著性差异（P〉0．05）；（2）与分化程度、淋巴结转移、临床分期有显著性差异（P〈0．01）；（3）HIF-1α和VEGF的表达呈正相关（P〈0．01）。结论 HIF-1α和VEGF联合检测对于肺癌的预后及治疗有一定的指导作用。

Expression and Significance of HIF-1α and VEGF in Non-small Cell Lung Cancer

Objective 　We examined the expression of HIF-1αgene and its relationship with VEGF protein in non-small lung cancer. Methods 　Immunohistochemical was used to examine the expression of HIF-1α and VEGF in 68 NSCLC tissue section . Results 　Positive HIF-1α and VEGF expression was noted 62 % and 69. 1 % in 68 NSCLC tissue section respectively. In 20 cases of non2malignant tissue sections , HIF-1αexpression was not detected and VEGF expression was only in 2 cases. The result showed : (1) there was no significant difference among age , sex , histopathological type , tumor size ( P > 0. 05) . (2) Tumor differentiation , lymph node metastasis and TNM stage correlated with the expression of HIF-1α and VEGF( P < 0. 01) . (3) HIF-1α level positively correlated with VEGF level ( P < 0. 01) . Conclusion 　The detection of VEGF and HIF-1αplay an important role in prognosis and t reatment of NSCLC.