| 诺福素对MCF-7人乳腺癌细胞的体内外抗癌药效学研究 |
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| 引用本文： | 于春芳,杨德宣,李琳娜,张庆林,袁守军. 诺福素对MCF-7人乳腺癌细胞的体内外抗癌药效学研究[J]. 解放军药学学报, 2011, 27(4): 303-306. DOI: 10.3969/j.issn.1008-9926.2011.04.07 |
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| 作者姓名： | 于春芳 杨德宣 李琳娜 张庆林 袁守军 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所, 北京,100850 |
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| 摘 要： | 目的 研究评价诺福素在体内体外对MCF-7人乳腺癌细胞的生长抑制作用.方法 按照抗癌药物临床前药效学评价原则,体外评价试验用MTT法,体内评价通过观察受试药物对MCF-7裸鼠移植瘤生长的影响,并与阳性药紫杉醇进行比较.结果 两批体外MTT法显示,诺福素抑制MCF-7细胞生长的半效抑制浓度分别为1.7762 nmol/L...
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| 关 键 词： | 诺福素 MCF-7 乳腺癌 抗瘤活性 |
Anti-cancer Evaluation of Epothilone B on Human Breast Cancer MCF-7 |
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| YU Chun-fang,YANG De-xuan,LI Lin-na,ZHANG Qing-lin,YUAN Shou-jun. Anti-cancer Evaluation of Epothilone B on Human Breast Cancer MCF-7[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2011, 27(4): 303-306. DOI: 10.3969/j.issn.1008-9926.2011.04.07 |
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| Authors: | YU Chun-fang YANG De-xuan LI Lin-na ZHANG Qing-lin YUAN Shou-jun |
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| Affiliation: | YU Chun-fang,YANG De-xuan,LI Lin-na,ZHANG Qing-lin,YUAN Shou-jun Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing100850,China |
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| Abstract: | Objective To evaluate the anti-cancer activity of Epothilone B on human breast cancer MCF-7 both in vivo and in vitro.Methods According to Principles of Preclinical Evaluation,the anti-cancer activity of Epothilone B in vitro was inspected by MTT method,while the activity in vivo was evaluated by observing the growth inhibition of MCF-7 xenograft tumors.Results The replicated MTT inspection showed that the IC50 of Epothilone B was both 1.7762 nmol/L and 0.8578 nmol/L.The maximum growth inhibition rate was 7... |
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| Keywords: | Epothilone B MCF-7 human breast tumor antitumor activity |
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