| 肺源性心脏病患者急性发作期和缓解期血浆CNP、ADM的变化及意义 |
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| 引用本文： | 刘志强,徐江祥,张敏,王霞,曹玲玲,周静,熊茂华,陈平君,金其武,夏斌,黄小红.肺源性心脏病患者急性发作期和缓解期血浆CNP、ADM的变化及意义[J].解放军保健医学杂志,2011(3). |
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| 作者姓名： | 刘志强 徐江祥 张敏 王霞 曹玲玲 周静 熊茂华 陈平君 金其武 夏斌 黄小红 |
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| 作者单位： | 九江市第一人民医院一病区; |
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| 摘 要： | 目的探讨C型利钠肽(CNP)及肾上腺髓质素(ADM)在慢性肺源性心脏病急性发作期和缓解期的水平及其临床意义。方法以放射免疫法检测观察组100例慢性肺源性心脏病急性加重期和缓解期及正常对照组60例健康体检者血浆CNP、ADM水平的变化,同时测定血氧分压和二氧化碳分压。结果 (1)观察组患者急性加重期和临床缓解期血浆CNP(60.21±15.48)ng/L,(48.95±29.40)ng/L],ADM(45.66±28.64)pg/ml,(28.95±14.35)pg/ml]水平均显著高于正常对照组(20.16±5.56)ng/L,(19.98±5.43)pg/ml],差异有统计学意义(P<0.01);(2)观察组急性加重期血浆CNP、ADM水平显著高于临床缓解期(P<0.01);(3)观察组患者CNP、ADM与血氧分压呈负相关(r=-0.622,-0.702,P<0.05),与血二氧化碳分压无明显相关性(r=0.205,0.233,P>0.05);(4)血浆CNP与ADM呈正相关(r=0.279,P<0.05)。结论血浆CNP、ADM水平变化可以反映慢性肺源性心脏病患者的临床病情变化。
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| 关 键 词： | 肺源性心脏病 C型利钠肽 肾上腺髓质素 |
Changes and significants of plasma CNP and ADM levels in acute exacerbation and clinical remission stages of patients with chronic pulmonary heart disease |
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| LIU Zhi-qiang,XU Jiang-xiang,ZHANG Min,et al.Changes and significants of plasma CNP and ADM levels in acute exacerbation and clinical remission stages of patients with chronic pulmonary heart disease[J].Journal Of Health Care And Medicine in Chinese Pla,2011(3). |
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| Authors: | LIU Zhi-qiang XU Jiang-xiang ZHANG Min |
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| Institution: | LIU Zhi-qiang,XU Jiang-xiang,ZHANG Min,et al (No.1 Department,the First People's Hospital of Jiujiang,Jiujiang 332000,China) |
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| Abstract: | Objective To investigate clinical significance of plasma c-type natriuretic peptide(CNP)and adrenomedullin(ADM)levels in acute exacerbation and clinical remission stages of patients with chronic pulmonary heart disease. Methods Plasma levels of CNP and ADM were measured by radioimmoassay in acute exacerbation and clinical remission stages of 100 patients with chronic pulmonary heart disease, oxygen partial pressure and carbon dioxide partial pressure were also measured at the same time. Plasma levels of CNP... |
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| Keywords: | Pulmonary heart disease C-type natriuretic peptide Adrenomedullin |
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