| 孟鲁司特钠分散片的人体生物等效性研究 |
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| 引用本文： | 林琳,马忠英,乔逸,杨林,文爱东.孟鲁司特钠分散片的人体生物等效性研究[J].解放军药学学报,2011,27(4):334-336. |
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| 作者姓名： | 林琳 马忠英 乔逸 杨林 文爱东 |
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| 作者单位： | 1. 解放军522医院药剂科, 河南洛阳,471003
2. 第四军医大学西京医院药剂科, 陕西西安,710032 |
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| 摘 要： | 目的 比较两种孟鲁司特钠制剂在人体的生物等效性.方法 20名健康男性志愿者随机、交叉、单剂量口服孟鲁司特钠分散片或孟鲁司特钠片10mg,液-质联用法测定人血浆中药物浓度,并用DAS 2.1.1软件计算药动学参数和生物利用度.结果 受试制剂与参比制剂Cmax分别为(408.6±79.1)、(498.7±114.2) n...
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| 关 键 词： | 孟鲁司特钠 液-质联用色谱法 药代动力学 生物等效性 |
Bioequivalence of Montelukast Dispersible Tablets in Healthy Volunteers |
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| LIN Lin,MA Zhong-ying,QIAO Yi,YANG Lin,WEN Ai-dong.Bioequivalence of Montelukast Dispersible Tablets in Healthy Volunteers[J].Pharmaceutical Journal of Chinese People's Liberation Army,2011,27(4):334-336. |
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| Authors: | LIN Lin MA Zhong-ying QIAO Yi YANG Lin WEN Ai-dong |
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| Institution: | ②①Department of Pharmacy,Hospital 522 of PLA,Luoyang471003,China;②Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi′an710032,China |
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| Abstract: | Objective To compare the bioequiavailability of two montelukast preparations in human volunteers.Methods A total of 20 healthy male volunteers were enrolled in a randomized crossover study in which the subjects were randomly assigned to receive a single dose of 10 mg montelukast dispersible tablets(test)or montelukast tablets(reference).The plasma concentration of montelukast was determined by liquid chromatography/tandem mass spectrometry,and the pharmacokinetic parameters and bioavailability were calculat... |
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| Keywords: | montelukast liquid chromatography/tandem mass spectrometry pharmacokinetics bioequiavailability |
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