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| 正交试验优选参夏和胃宁胶囊的制粒工艺 | |
| 引用本文： | 杨锋,李茜,费嘉,肖女,史琪荣.正交试验优选参夏和胃宁胶囊的制粒工艺[J].解放军药学学报,2011,27(4):311-313. |
| 作者姓名： | 杨锋 李茜 费嘉 肖女 史琪荣 |
| 作者单位： | 1. 北京军区总医院药剂科, 北京,100700 2. 中国海洋石油总公司医务室, 北京,100010 3. 北京军区总医院药剂科机关第一门诊部药械科, 北京,100700 |
| 摘 要： | 目的 优选参夏和胃宁胶囊喷雾制粒的最佳工艺条件.方法 采用正交试验设计以颗粒的流动性和吸湿性为考察指标,对制粒过程的丰主因素进行考察.结果 最佳工艺参数为喷雾制粒的雾化压力0.3 mPa、干燥时间为40 min、浸膏相对密度为1.1～1.2、淀粉量为0.3倍.结论 该方法制出的颗粒流动性好,不易吸湿,易于溶出,性质稳定... |
| 关 键 词： | 参夏和胃宁胶囊 喷雾制粒 正交试验 |
Orthogonal Experiments for Granulating Process of Shenxia and Weining Capsules |
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| YANG Feng,LI Qian,FEI Jia,XIAO Nv,SHI Qi-rong.Orthogonal Experiments for Granulating Process of Shenxia and Weining Capsules[J].Pharmaceutical Journal of Chinese People's Liberation Army,2011,27(4):311-313. | |
| Authors: | YANG Feng LI Qian FEI Jia XIAO Nv SHI Qi-rong |
| Institution: | ①①Pharmaceutical Department,Beijing Military General Hospital,Beijing100700,China;②Clinic,China National Offshore Oil Corporation,Beijing100010,China;③Pharmaceutical Department,Chengdu Military Command No.1 Clinic of the Administrative Office,Chengdu610011,China |
| Abstract: | Objective To optimize the process of Shenxia and Weining capsules.Methods The major part of spray granulating technology was investigated by orthogonal experiment.Fluidity and hygroscopy were used as the index.Results The optimum technical parameters were 0.3 mPa spraying pressure,40 min of drying time,1.1-1.2 relative density of the extract,and one third the amount of amylum.Conclusion The granules prepared with this method are highly fluid,anti-wet,easily to dissoluable and stable. |
| Keywords: | Shenxia and Weining capsules spray granulation orthogonal experiments |
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