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| 开心散对缺氧和力竭运动小鼠的抗氧化及抗疲劳作用研究 | |
| 引用本文： | 曹寅,胡园,赵海霞,刘明,黄志雄,韦颖梅,刘屏.开心散对缺氧和力竭运动小鼠的抗氧化及抗疲劳作用研究[J].解放军药学学报,2011,27(4):307-310,313. |
| 作者姓名： | 曹寅 胡园 赵海霞 刘明 黄志雄 韦颖梅 刘屏 |
| 作者单位： | 1. 安徽蚌埠医学院药学系, 安徽蚌埠,233003 2. 解放军总医院药理研究室, 北京,100853 3. 天津中医药大学, 天津,300193 |
| 基金项目： | 总后十一五基金,No.06MA276; 国家科技部重大项目,No.2008ZXJ09004-028 |
| 摘 要： | 目的 研究中药复方开心散的耐缺氧及抗疲劳作用.方法 通过小鼠常压耐缺氧实验观察开心散的耐缺氧作用及对脑组织中SOD活力和MDA含量的影响.观察开心散在小鼠转轮疲劳模型上运动力竭小鼠被电击的次数和对肝糖原、肌糖原、肌乳酸含量和血清中SOD活力和MDA含量的影响.结果 中、高剂量(250、500 mg/kg)组的开心散能明... |
| 关 键 词： | 开心散 耐缺氧 抗疲劳 |
A Study on Anti-oxidant Activity and Anti-fatigue Effect of Kaixinsan of Laboratory Mice |
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| CAO Yin,HU Yuan,ZHAO Hai-xia,LIU Ming,HUANG Zhi-xiong,WEI Ying-mei,LIU Ping.A Study on Anti-oxidant Activity and Anti-fatigue Effect of Kaixinsan of Laboratory Mice[J].Pharmaceutical Journal of Chinese People's Liberation Army,2011,27(4):307-310,313. | |
| Authors: | CAO Yin HU Yuan ZHAO Hai-xia LIU Ming HUANG Zhi-xiong WEI Ying-mei LIU Ping |
| Institution: | ②①Bengbu Medical College,Bengbu233030,China;②Department of Clinical Pharmacology,General Hospital of PLA,Beijing100853,China;③Tianjin University of Traditional Chinese Medicine,Tianjin300193,China |
| Abstract: | Objective To observe the anti-hypoxia and anti-fatigue effect of Kaixinsan.Methods Mice were subjected to anti-hypoxia experiments under ordinary pressure to observe the anti-hypoxia effect of Kaixinsan and the changes of SOD and MDA in their brain.The effect of Kaixinsan on electric shock times in exhaustive exercise,liver glycogen,muscle glycogen and muscle lactic acid,serum SOD and MDA of the fatigue mice induced by wheel running was observed.Results Kaixinsan in middle dosage treatment(250 mg/kg) group ... |
| Keywords: | Kaixinsan anti-hypoxia anti-fatigue |
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