Effect of ephedrine on the onset time of succinylcholine |
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Authors: | Ganidagli S Cengiz M Baysal Z |
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Affiliation: | Department of Anaesthesiology and Reanimation, Harran University Medical School, Sanliurfa, Turkey. sganidagli@hotmail.com |
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Abstract: | BACKGROUND: The aim of this study was to evaluate the effect of ephedrine administered prior to induction of anaesthesia on the onset time of succinylcholine for endotracheal intubation. METHODS: Patients were randomly assigned to receive intravenously (i.v.) either 70 microg kg(-1) of ephedrine (Group I; n = 25) or saline (Group II; n = 25) 3 min before induction of anaesthesia. Induction of anaesthesia was provided with propofol 2 mg kg(-1) plus remifentanil 1 microg kg(-1). Onset time and duration of muscle fasciculation and onset time of succinylcholine were recorded. Intubation was attempted after establishment of 100% thumb relaxation and difficulties were recorded. Heart rate, pulse oxymetry (SpO2) and mean arterial pressure (MAP) were also recorded. RESULTS: The onset time of succinylcholine were significantly (P < 0.001) shorter in Group I (26 +/- 4 s), when compared with Group II (43 +/- 6 s). Patients in Group I were intubated at 49 +/- 7 s compared with 68 +/- 10 s in Group II. The score of intubation was similar in both groups. Duration of muscle fasciculation was longer in Group II. Heart rate and MAP increased significantly (P < 0.05) after ephedrine injection, compared with the baseline value in Group I. CONCLUSIONS: The onset time of succinylcholine can be shortened with ephedrine pretreatment. |
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Keywords: | Ephedrine onset time rapid intubation succinylcholine |
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