Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia |
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| Authors: | Sujit Kumar Mohanty Pranavkumar Shivakumar Gregg Sabla Jorge A Bezerra |
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| Institution: | (1) Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics of the University of Cincinnati, Cincinnati, OH, USA |
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| Abstract: | Background Livers of infants with biliary atresia and of neonatal mice infected with rotavirus (RRV) have increased expression of interferon-gamma
(IFNγ) and interleukin (IL)-12. While the expression of IFNγ regulates the obstruction of extrahepatic bile ducts by lymphocytes,
the role of IL-12 in the pathogenesis of biliary obstruction is unknown. Based on the role of IL-12 as a key proinflammatory
cytokine, we hypothesized that loss of IL-12 prevents the obstruction of extrahepatic bile ducts. |
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