| 三环类环氧合酶-2选择性抑制剂的构效关系 |
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| 引用本文： | 汪凤颖,李顺来,王清. 三环类环氧合酶-2选择性抑制剂的构效关系[J]. 药学进展, 2004, 28(11): 485-490 |
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| 作者姓名： | 汪凤颖 李顺来 王清 |
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| 作者单位： | 北京化工大学理学院,北京,100029 |
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| 摘 要： | 按照中心环的结构分类综述三环类环氧合酶-2(COX-2)选择性抑制剂的构效关系。三环类COX-2选择性抑制剂是目前非甾体抗炎药中研究最多、也是最富有成果的一类化合物。
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| 关 键 词： | 非甾体抗炎药 环氧合酶-2 三环类环氧合酶-2选择性抑制剂 构效关系 |
| 文章编号： | 1001-5094(2004)11-0485-06 |
| 修稿时间： | 2004-07-11 |
Studies on the Structure-activity Relationship of Tricyclic Cycloxygenase-2 Selective Inhibitors |
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| WANG Feng-ying,LI Shun-lai,WANG Qing. Studies on the Structure-activity Relationship of Tricyclic Cycloxygenase-2 Selective Inhibitors[J]. Progress in Pharmaceutical Sciences, 2004, 28(11): 485-490 |
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| Authors: | WANG Feng-ying LI Shun-lai WANG Qing |
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| Affiliation: | WANG Feng-ying,LI Shun-lai*,WANG Qing |
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| Abstract: | Tricyclic cycloxygenase-2 (C OX-2) selective inhibitors are the series of NSAIDs that are investigated most often and successfully. Ba sed on the center cyclic structures, their structure-activity relationship was reviewed. [ |
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| Keywords: | NSAID Cycloxygenase-2 Tricyclic cycloxygenase -2 selective inhibitor Structure-activity relationship |
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